TMM72_MOUSE
ID TMM72_MOUSE Reviewed; 275 AA.
AC Q8C3K5; Q0VGN8; Q3URE2; Q8C7L8; Q8C7X5; Q8CC57;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Transmembrane protein 72;
GN Name=Tmem72;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Diencephalon, Hippocampus, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK033856; BAC28497.1; -; mRNA.
DR EMBL; AK049048; BAC33524.1; -; mRNA.
DR EMBL; AK049938; BAC33994.1; -; mRNA.
DR EMBL; AK085603; BAC39484.1; -; mRNA.
DR EMBL; AK141578; BAE24746.1; -; mRNA.
DR EMBL; BC093486; AAH93486.1; -; mRNA.
DR EMBL; BC116440; AAI16441.1; -; mRNA.
DR EMBL; BC116441; AAI16442.1; -; mRNA.
DR CCDS; CCDS20462.1; -.
DR RefSeq; NP_848883.2; NM_178768.4.
DR AlphaFoldDB; Q8C3K5; -.
DR STRING; 10090.ENSMUSP00000057942; -.
DR PhosphoSitePlus; Q8C3K5; -.
DR PaxDb; Q8C3K5; -.
DR PRIDE; Q8C3K5; -.
DR ProteomicsDB; 259589; -.
DR Antibodypedia; 50461; 22 antibodies from 11 providers.
DR Ensembl; ENSMUST00000056623; ENSMUSP00000057942; ENSMUSG00000048108.
DR GeneID; 319776; -.
DR KEGG; mmu:319776; -.
DR UCSC; uc009dkr.1; mouse.
DR CTD; 643236; -.
DR MGI; MGI:2442707; Tmem72.
DR VEuPathDB; HostDB:ENSMUSG00000048108; -.
DR eggNOG; ENOG502RXMX; Eukaryota.
DR GeneTree; ENSGT00390000006888; -.
DR HOGENOM; CLU_067357_0_0_1; -.
DR InParanoid; Q8C3K5; -.
DR OMA; FKCQPGS; -.
DR OrthoDB; 1128211at2759; -.
DR PhylomeDB; Q8C3K5; -.
DR TreeFam; TF336492; -.
DR BioGRID-ORCS; 319776; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem72; mouse.
DR PRO; PR:Q8C3K5; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8C3K5; protein.
DR Bgee; ENSMUSG00000048108; Expressed in animal zygote and 43 other tissues.
DR ExpressionAtlas; Q8C3K5; baseline and differential.
DR Genevisible; Q8C3K5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR032055; TMEM72.
DR PANTHER; PTHR28474; PTHR28474; 1.
DR Pfam; PF16054; TMEM72; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..275
FT /note="Transmembrane protein 72"
FT /id="PRO_0000319056"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 139..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 17
FT /note="L -> S (in Ref. 1; BAE24746)"
FT /evidence="ECO:0000305"
FT CONFLICT 23
FT /note="A -> T (in Ref. 1; BAC28497)"
FT /evidence="ECO:0000305"
FT CONFLICT 37
FT /note="R -> P (in Ref. 1; BAE24746)"
FT /evidence="ECO:0000305"
FT CONFLICT 40
FT /note="S -> G (in Ref. 1; BAE24746)"
FT /evidence="ECO:0000305"
FT CONFLICT 134
FT /note="K -> E (in Ref. 1; BAC33994)"
FT /evidence="ECO:0000305"
FT CONFLICT 195
FT /note="K -> E (in Ref. 1; BAC33524 and 2; AAH93486)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 275 AA; 30372 MW; 8C046236FB797224 CRC64;
MKLQVFWTGL EYTCRLLGIA TAAVLIGVGT ETFLRGRFKS LAFYLLFTGV TISVCEGTYF
VAQLLAICFK CQPGSLAHRA KERAHWLGCF QKFLAYMLLS VACFLHPVLV WHVTIPGSML
IITGLAYFLL SKRKKKKAAP EVAPPTEQYT DPSSSVVSTT GSGDTEQTYT FHEAFKEGPG
SFFIHMKSIL KGTKKPRVLQ TQDTLMELAL EPADSLAKKK QVHFEDNVVR IIPSLTEGLG
DSDSEPEETS SDTTPIIPPS QTPHFLPSLM ATDLF
