BTBDA_MOUSE
ID BTBDA_MOUSE Reviewed; 475 AA.
AC Q80X66;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=BTB/POZ domain-containing protein 10;
DE AltName: Full=Glucose metabolism-related protein 1 {ECO:0000303|PubMed:21267538};
GN Name=Btbd10; Synonyms=Gmrp1 {ECO:0000303|PubMed:21267538};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PROTEIN SEQUENCE OF 363-368, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [3]
RP TISSUE SPECIFICITY, INTERACTION WITH AKT1; AKT2; AKT3; PPP2CA AND PPP1CA,
RP SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=18160256; DOI=10.1016/j.cellsig.2007.11.004;
RA Nawa M., Kanekura K., Hashimoto Y., Aiso S., Matsuoka M.;
RT "A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits
RT familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal
RT death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB.";
RL Cell. Signal. 20:493-505(2008).
RN [4]
RP FUNCTION.
RX PubMed=21267538; DOI=10.1007/s00125-011-2048-1;
RA Wang X., Liu Y., Yang Z., Zhang Z., Zhou W., Ye Z., Zhang W., Zhang S.,
RA Yang Z., Feng X., Chen F., Hu R.;
RT "Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic beta
RT cell proliferation and apoptosis via activation of Akt signalling pathway
RT in rats and mice.";
RL Diabetologia 54:852-863(2011).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=24156551; DOI=10.1186/1471-2091-14-27;
RA Nawa M., Matsuoka M.;
RT "KCTD20, a relative of BTBD10, is a positive regulator of Akt.";
RL BMC Biochem. 14:27-27(2013).
CC -!- FUNCTION: Plays a major role as an activator of AKT family members by
CC inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs
CC activated. Plays a role in preventing motor neuronal death and in
CC accelerating the growth of pancreatic beta cells.
CC {ECO:0000269|PubMed:18160256, ECO:0000269|PubMed:21267538}.
CC -!- SUBUNIT: Interacts (via C-terminal 330-amino-acid region) with AKT1;
CC AKT2 and AKT3 (PubMed:18160256). Interacts with PPP2CA and PPP1CA
CC (PubMed:18160256). {ECO:0000269|PubMed:18160256}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BSF8}. Cytoplasm
CC {ECO:0000269|PubMed:18160256}. Note=Colocalizes with KCTD20 in
CC filamentous structures. {ECO:0000269|PubMed:24156551}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed (at protein level).
CC {ECO:0000269|PubMed:18160256}.
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DR EMBL; BC050781; AAH50781.1; -; mRNA.
DR CCDS; CCDS21755.1; -.
DR RefSeq; NP_598461.1; NM_133700.2.
DR RefSeq; XP_006508223.1; XM_006508160.2.
DR RefSeq; XP_011240192.1; XM_011241890.1.
DR AlphaFoldDB; Q80X66; -.
DR SMR; Q80X66; -.
DR BioGRID; 213065; 7.
DR IntAct; Q80X66; 2.
DR MINT; Q80X66; -.
DR STRING; 10090.ENSMUSP00000048530; -.
DR iPTMnet; Q80X66; -.
DR PhosphoSitePlus; Q80X66; -.
DR EPD; Q80X66; -.
DR PaxDb; Q80X66; -.
DR PRIDE; Q80X66; -.
DR ProteomicsDB; 273777; -.
DR Antibodypedia; 24598; 215 antibodies from 21 providers.
DR DNASU; 68815; -.
DR Ensembl; ENSMUST00000047091; ENSMUSP00000048530; ENSMUSG00000038187.
DR GeneID; 68815; -.
DR KEGG; mmu:68815; -.
DR UCSC; uc009jhl.1; mouse.
DR CTD; 84280; -.
DR MGI; MGI:1916065; Btbd10.
DR VEuPathDB; HostDB:ENSMUSG00000038187; -.
DR eggNOG; KOG3840; Eukaryota.
DR GeneTree; ENSGT00390000007975; -.
DR InParanoid; Q80X66; -.
DR OMA; HEGLNQQ; -.
DR PhylomeDB; Q80X66; -.
DR TreeFam; TF314369; -.
DR BioGRID-ORCS; 68815; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Btbd10; mouse.
DR PRO; PR:Q80X66; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q80X66; protein.
DR Bgee; ENSMUSG00000038187; Expressed in primary oocyte and 243 other tissues.
DR ExpressionAtlas; Q80X66; baseline and differential.
DR Genevisible; Q80X66; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:1901215; P:negative regulation of neuron death; IDA:UniProtKB.
DR GO; GO:0042327; P:positive regulation of phosphorylation; IDA:UniProtKB.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR039886; BTBD10/KCTD20.
DR InterPro; IPR039885; BTBD10/KCTD20_BTB/POZ.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR21637; PTHR21637; 1.
DR Pfam; PF16017; BTB_3; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Nucleus; Reference proteome.
FT CHAIN 1..475
FT /note="BTB/POZ domain-containing protein 10"
FT /id="PRO_0000228986"
FT DOMAIN 167..241
FT /note="BTB"
FT REGION 1..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..475
FT /note="Interaction with AKT family members"
FT /evidence="ECO:0000269|PubMed:18160256"
FT REGION 451..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..110
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 475 AA; 53772 MW; E64BA738C739241A CRC64;
MAGRPHPYDS NSSDPENWDR KLHSRPRKLY KHSSSASRVA KGGVDHTKMS LHGASGGHER
SRDRRRSSDR SRDSSHERAE SQLTPCIRNV TSPTRQHHIE REKDHSSSRP SSPRPQRASP
NGSMSSAGNS SRNSSQSSSD GSCKTSGEMV FVYENAKEGA RNVRTSERVT LIVDNTRFVV
DPSIFTAQPN TMLGRMFGSG REHNFTRPNE KGEYEVAEGI GSTVFRAILD YYKTGIIRCP
DGISIPELRE ACDYLCISFE YSTIKCRDLS ALMHELSNDG ARRQFEFYLE EMILPLMVAS
AQSGERECHI VVLTDDDVVD WDEEYPPQMG EEYSQIIYST KLYRFFKYIE NRDVAKSVLK
ERGLKKIRLG IEGYPTYKEK VKKRPGGRPE VIYNYVQRPF IRMSWEKEEG KSRHVDFQCV
KSKSITNLAA AAADIPQDQL VVMHPTPQVD ELDILPSHPA SGNNDLDPDA QNPML
