ID   TMM79_RAT               Reviewed;         391 AA.
AC   Q3T1H8;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Transmembrane protein 79;
DE   AltName: Full=Mattrin;
GN   Name=Tmem79;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Contributes to the epidermal integrity and skin barrier
CC       function. Plays a role in the lamellar granule (LG) secretory system
CC       and in the stratum corneum (SC) epithelial cell formation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000250}. Golgi apparatus, trans-
CC       Golgi network {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}. Note=Colocalized with TGOLN2 in the
CC       trans-Golgi network. Colocalized with LAMP1 in the lysosome (By
CC       similarity). {ECO:0000250}.
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DR   EMBL; BC101913; AAI01914.1; -; mRNA.
DR   RefSeq; NP_001029068.1; NM_001033896.1.
DR   RefSeq; XP_006232699.1; XM_006232637.3.
DR   RefSeq; XP_008759371.1; XM_008761149.1.
DR   RefSeq; XP_017446369.1; XM_017590880.1.
DR   RefSeq; XP_017446370.1; XM_017590881.1.
DR   AlphaFoldDB; Q3T1H8; -.
DR   STRING; 10116.ENSRNOP00000026414; -.
DR   PaxDb; Q3T1H8; -.
DR   Ensembl; ENSRNOT00000092349; ENSRNOP00000075750; ENSRNOG00000019414.
DR   GeneID; 310626; -.
DR   KEGG; rno:310626; -.
DR   UCSC; RGD:1309886; rat.
DR   CTD; 84283; -.
DR   RGD; 1309886; Tmem79.
DR   eggNOG; ENOG502QVUB; Eukaryota.
DR   GeneTree; ENSGT00390000002390; -.
DR   HOGENOM; CLU_062246_1_0_1; -.
DR   InParanoid; Q3T1H8; -.
DR   OMA; YYMFLVE; -.
DR   OrthoDB; 963760at2759; -.
DR   PhylomeDB; Q3T1H8; -.
DR   TreeFam; TF333310; -.
DR   PRO; PR:Q3T1H8; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000019414; Expressed in esophagus and 17 other tissues.
DR   Genevisible; Q3T1H8; RN.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0032588; C:trans-Golgi network membrane; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0070268; P:cornification; ISO:RGD.
DR   GO; GO:0042335; P:cuticle development; ISO:RGD.
DR   GO; GO:0002070; P:epithelial cell maturation; ISS:UniProtKB.
DR   GO; GO:0061436; P:establishment of skin barrier; ISS:UniProtKB.
DR   GO; GO:0031069; P:hair follicle morphogenesis; ISO:RGD.
DR   GO; GO:0045684; P:positive regulation of epidermis development; ISS:UniProtKB.
DR   GO; GO:0045055; P:regulated exocytosis; ISS:UniProtKB.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..391
FT                   /note="Transmembrane protein 79"
FT                   /id="PRO_0000254120"
FT   TOPO_DOM        1..200
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        222..240
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..279
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        301..309
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        331..339
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        340..360
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        361..391
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   391 AA;  43363 MW;  5439F44E53573C46 CRC64;
     MTEPETLALL DMKDTEISEK SPPQASVLQP EEEGGTESPG AESLRVGSSV GSPTVREGPE
     DGPDSTISEA ATLPWGTDPH PSAPLPDPPG WRDIGPELLE SEAPIKSEEP LKEDANLLPE
     KTVRAFVPID LQCIERKPQE ERIKHREAGP GELRNFLPAR LSHPEPPERK WAEAVVRPPG
     RSCGGCGSCG GREALRAVAS VVAALIFFPC LLYGAYAFLP FDAPRLPTMS SRLVYTLRCG
     VFATFPIVLG LLVYGLSLLC FSALRPFGEP RREVEIHRQY VAQSVQLFIL YFFNLAVLST
     YLPQDTLKLL PLLTGLFAIS RLIYWLTFAV GRSFRGFGYG LTFLPLLAML VWNLYYMFVV
     EPERMLSASE SRLDYPDHVR SVSDYRPRSW G