TMM80_MOUSE
ID TMM80_MOUSE Reviewed; 123 AA.
AC Q9D3H0; Q8BQL4;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Transmembrane protein 80;
GN Name=Tmem80;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, Head, Kidney, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=26982032; DOI=10.1371/journal.pbio.1002416;
RA Li C., Jensen V.L., Park K., Kennedy J., Garcia-Gonzalo F.R., Romani M.,
RA De Mori R., Bruel A.L., Gaillard D., Doray B., Lopez E., Riviere J.B.,
RA Faivre L., Thauvin-Robinet C., Reiter J.F., Blacque O.E., Valente E.M.,
RA Leroux M.R.;
RT "MKS5 and CEP290 dependent assembly pathway of the ciliary transition
RT zone.";
RL PLoS Biol. 14:E1002416-E1002416(2016).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}. Cell projection, cilium
CC {ECO:0000269|PubMed:26982032}. Note=Localizes at the transition zone, a
CC region between the basal body and the ciliary axoneme.
CC {ECO:0000269|PubMed:26982032}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D3H0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D3H0-2; Sequence=VSP_025611;
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DR EMBL; AK017460; BAB30753.1; -; mRNA.
DR EMBL; AK049405; BAC33737.1; -; mRNA.
DR EMBL; AK134821; BAE22300.1; -; mRNA.
DR EMBL; AK169083; BAE40867.1; -; mRNA.
DR EMBL; BC022756; AAH22756.1; -; mRNA.
DR CCDS; CCDS22008.1; -. [Q9D3H0-1]
DR RefSeq; NP_001135422.1; NM_001141950.1. [Q9D3H0-1]
DR RefSeq; NP_082073.1; NM_027797.3. [Q9D3H0-1]
DR RefSeq; XP_011248160.1; XM_011249858.1. [Q9D3H0-1]
DR AlphaFoldDB; Q9D3H0; -.
DR STRING; 10090.ENSMUSP00000118223; -.
DR PhosphoSitePlus; Q9D3H0; -.
DR PaxDb; Q9D3H0; -.
DR PRIDE; Q9D3H0; -.
DR Antibodypedia; 59030; 123 antibodies from 13 providers.
DR DNASU; 71448; -.
DR Ensembl; ENSMUST00000026578; ENSMUSP00000026578; ENSMUSG00000025505. [Q9D3H0-1]
DR Ensembl; ENSMUST00000126510; ENSMUSP00000123330; ENSMUSG00000025505. [Q9D3H0-1]
DR Ensembl; ENSMUST00000128906; ENSMUSP00000117306; ENSMUSG00000025505. [Q9D3H0-2]
DR Ensembl; ENSMUST00000132061; ENSMUSP00000118223; ENSMUSG00000025505. [Q9D3H0-1]
DR Ensembl; ENSMUST00000133012; ENSMUSP00000116695; ENSMUSG00000025505. [Q9D3H0-1]
DR Ensembl; ENSMUST00000145184; ENSMUSP00000117633; ENSMUSG00000025505. [Q9D3H0-2]
DR GeneID; 71448; -.
DR KEGG; mmu:71448; -.
DR UCSC; uc009kkq.2; mouse. [Q9D3H0-1]
DR CTD; 283232; -.
DR MGI; MGI:1918698; Tmem80.
DR VEuPathDB; HostDB:ENSMUSG00000025505; -.
DR eggNOG; KOG4502; Eukaryota.
DR GeneTree; ENSGT00940000153899; -.
DR HOGENOM; CLU_135948_0_0_1; -.
DR InParanoid; Q9D3H0; -.
DR OMA; FLHFYSG; -.
DR OrthoDB; 1584392at2759; -.
DR PhylomeDB; Q9D3H0; -.
DR TreeFam; TF323824; -.
DR BioGRID-ORCS; 71448; 1 hit in 70 CRISPR screens.
DR PRO; PR:Q9D3H0; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9D3H0; protein.
DR Bgee; ENSMUSG00000025505; Expressed in humerus cartilage element and 238 other tissues.
DR Genevisible; Q9D3H0; MM.
DR GO; GO:0035869; C:ciliary transition zone; IDA:WormBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:1905515; P:non-motile cilium assembly; IBA:GO_Central.
DR InterPro; IPR019184; Uncharacterised_TM-17.
DR PANTHER; PTHR13531; PTHR13531; 1.
DR Pfam; PF09799; Transmemb_17; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..123
FT /note="Transmembrane protein 80"
FT /id="PRO_0000287874"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 26..56
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025611"
SQ SEQUENCE 123 AA; 13473 MW; D529466CD787D6D0 CRC64;
MLFHLSGLYS ALYFLATLLM IVYKSQVFSY PCNCLALDLV LLLLMGILKV AQLYLGTKGN
LMEAEVPLAA SLAFTAVGGL LSVHFLLWQT LVLWMDSVLS TVLLVLHGLE AGLQVVVIAD
FIR
