ID   TMM81_BOVIN             Reviewed;         276 AA.
AC   Q0VCB1;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Transmembrane protein 81;
DE   Flags: Precursor;
GN   Name=TMEM81;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; BC120262; AAI20263.1; -; mRNA.
DR   RefSeq; NP_001068933.1; NM_001075465.2.
DR   AlphaFoldDB; Q0VCB1; -.
DR   STRING; 9913.ENSBTAP00000021201; -.
DR   PaxDb; Q0VCB1; -.
DR   Ensembl; ENSBTAT00000021201; ENSBTAP00000021201; ENSBTAG00000015945.
DR   GeneID; 510784; -.
DR   KEGG; bta:510784; -.
DR   CTD; 388730; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015945; -.
DR   VGNC; VGNC:36114; TMEM81.
DR   eggNOG; ENOG502RYDZ; Eukaryota.
DR   GeneTree; ENSGT00390000006349; -.
DR   InParanoid; Q0VCB1; -.
DR   OMA; NATTCTV; -.
DR   OrthoDB; 1256219at2759; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000015945; Expressed in spermatid and 96 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR039293; TMEM81.
DR   PANTHER; PTHR35670; PTHR35670; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..276
FT                   /note="Transmembrane protein 81"
FT                   /id="PRO_0000287875"
FT   TOPO_DOM        25..225
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247..276
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          83..176
FT                   /note="Ig-like"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        211
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        104..160
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   276 AA;  30344 MW;  742E2C1C5701811D CRC64;
     MKTSATSFIP GSLVLAFCLP VVATSPKTLA IPEKLQEAVG KVTVNATTCT VICGLGFKEE
     TVCEVGPDGV RRKCKSQRLE CLTNWLCGML HFTLLIGKEF KLSCLSPDIL EIGQGAFRFT
     WRLARGIIST DDEVFKPFRA SSYFIKFQSI QEYDSGTYRC DVQLLKNLRL VKRLYFGLRV
     LPPNLVNLNF HQSLTEDQKL VDEGLEVNLD NYSRPQHPPW KKKVAIAVGI GVAGGVTGGV
     LVSIVLCGRL SVIHSSASLE TLQALLPKGG MLRKPD