TMM81_HUMAN
ID TMM81_HUMAN Reviewed; 255 AA.
AC Q6P7N7; Q6UVZ4;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Transmembrane protein 81;
DE Flags: Precursor;
GN Name=TMEM81; ORFNames=UNQ2788/PRO7178;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLN-77.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY359081; AAQ89440.1; -; mRNA.
DR EMBL; AL583832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC061592; AAH61592.1; -; mRNA.
DR CCDS; CCDS1450.1; -.
DR RefSeq; NP_976310.1; NM_203376.1.
DR AlphaFoldDB; Q6P7N7; -.
DR BioGRID; 132828; 1.
DR STRING; 9606.ENSP00000356135; -.
DR GlyGen; Q6P7N7; 2 sites, 1 O-linked glycan (1 site).
DR PhosphoSitePlus; Q6P7N7; -.
DR BioMuta; TMEM81; -.
DR DMDM; 74758298; -.
DR MassIVE; Q6P7N7; -.
DR PaxDb; Q6P7N7; -.
DR PeptideAtlas; Q6P7N7; -.
DR PRIDE; Q6P7N7; -.
DR Antibodypedia; 59281; 11 antibodies from 7 providers.
DR DNASU; 388730; -.
DR Ensembl; ENST00000367167.4; ENSP00000356135.3; ENSG00000174529.7.
DR GeneID; 388730; -.
DR KEGG; hsa:388730; -.
DR MANE-Select; ENST00000367167.4; ENSP00000356135.3; NM_203376.2; NP_976310.1.
DR UCSC; uc001hbt.3; human.
DR CTD; 388730; -.
DR DisGeNET; 388730; -.
DR GeneCards; TMEM81; -.
DR HGNC; HGNC:32349; TMEM81.
DR HPA; ENSG00000174529; Low tissue specificity.
DR neXtProt; NX_Q6P7N7; -.
DR OpenTargets; ENSG00000174529; -.
DR PharmGKB; PA143485633; -.
DR VEuPathDB; HostDB:ENSG00000174529; -.
DR eggNOG; ENOG502RYDZ; Eukaryota.
DR GeneTree; ENSGT00390000006349; -.
DR HOGENOM; CLU_093881_0_0_1; -.
DR InParanoid; Q6P7N7; -.
DR OMA; NATTCTV; -.
DR OrthoDB; 1256219at2759; -.
DR PhylomeDB; Q6P7N7; -.
DR TreeFam; TF333177; -.
DR PathwayCommons; Q6P7N7; -.
DR BioGRID-ORCS; 388730; 9 hits in 1079 CRISPR screens.
DR GenomeRNAi; 388730; -.
DR Pharos; Q6P7N7; Tdark.
DR PRO; PR:Q6P7N7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6P7N7; protein.
DR Bgee; ENSG00000174529; Expressed in thymus and 97 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR039293; TMEM81.
DR PANTHER; PTHR35670; PTHR35670; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..255
FT /note="Transmembrane protein 81"
FT /id="PRO_0000287876"
FT TOPO_DOM 31..226
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 227..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 248..255
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 83..171
FT /note="Ig-like"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..160
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 77
FT /note="R -> Q (in dbSNP:rs4951168)"
FT /evidence="ECO:0000269|PubMed:12975309"
FT /id="VAR_032353"
FT VARIANT 100
FT /note="F -> S (in dbSNP:rs16855059)"
FT /id="VAR_032354"
SQ SEQUENCE 255 AA; 28468 MW; 27FDEBE4FA76E021 CRC64;
MKVLATSFVL GSLGLAFYLP LVVTTPKTLA IPEKLQEAVG KVIINATTCT VTCGLGYKEE
TVCEVGPDGV RRKCQTRRLE CLTNWICGML HFTILIGKEF ELSCLSSDIL EFGQEAFRFT
WRLARGVIST DDEVFKPFQA NSHFVKFKYA QEYDSGTYRC DVQLVKNLRL VKRLYFGLRV
LPPNLVNLNF HQSLTEDQKL IDEGLEVNLD SYSKPHHPKW KKKVASALGI GIAIGVVGGV
LVRIVLCALR GGLQQ
