TMM81_MOUSE
ID TMM81_MOUSE Reviewed; 259 AA.
AC Q9D5K1; Q4VBF9;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Transmembrane protein 81;
DE Flags: Precursor;
GN Name=Tmem81;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AK015245; BAB29762.1; -; mRNA.
DR EMBL; AK045585; BAC32424.1; -; mRNA.
DR EMBL; BC095954; AAH95954.1; -; mRNA.
DR EMBL; BC120863; AAI20864.1; -; mRNA.
DR EMBL; BC132045; AAI32046.1; -; mRNA.
DR CCDS; CCDS15287.1; -.
DR RefSeq; NP_083301.1; NM_029025.3.
DR AlphaFoldDB; Q9D5K1; -.
DR STRING; 10090.ENSMUSP00000139911; -.
DR GlyGen; Q9D5K1; 3 sites.
DR iPTMnet; Q9D5K1; -.
DR PhosphoSitePlus; Q9D5K1; -.
DR PaxDb; Q9D5K1; -.
DR PRIDE; Q9D5K1; -.
DR ProteomicsDB; 259134; -.
DR Antibodypedia; 59281; 11 antibodies from 7 providers.
DR DNASU; 74626; -.
DR Ensembl; ENSMUST00000058167; ENSMUSP00000062565; ENSMUSG00000048174.
DR Ensembl; ENSMUST00000188789; ENSMUSP00000139911; ENSMUSG00000048174.
DR GeneID; 74626; -.
DR KEGG; mmu:74626; -.
DR UCSC; uc007coz.2; mouse.
DR CTD; 388730; -.
DR MGI; MGI:1921876; Tmem81.
DR VEuPathDB; HostDB:ENSMUSG00000048174; -.
DR eggNOG; ENOG502RYDZ; Eukaryota.
DR GeneTree; ENSGT00390000006349; -.
DR HOGENOM; CLU_093881_0_0_1; -.
DR InParanoid; Q9D5K1; -.
DR OMA; NATTCTV; -.
DR OrthoDB; 1256219at2759; -.
DR PhylomeDB; Q9D5K1; -.
DR TreeFam; TF333177; -.
DR BioGRID-ORCS; 74626; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q9D5K1; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9D5K1; protein.
DR Bgee; ENSMUSG00000048174; Expressed in spermatid and 127 other tissues.
DR Genevisible; Q9D5K1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR039293; TMEM81.
DR PANTHER; PTHR35670; PTHR35670; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..259
FT /note="Transmembrane protein 81"
FT /id="PRO_0000287877"
FT TOPO_DOM 26..223
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..259
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 80..173
FT /note="Ig-like"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 208
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..157
FT /evidence="ECO:0000250"
FT CONFLICT 253
FT /note="S -> N (in Ref. 2; AAH95954)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 259 AA; 28748 MW; 776C59D969DA51BC CRC64;
MKTGAIVFIL RSLLSITYLP LVLMTLDIPE ELQKAVGRVI VNATGCSVTC GLGYKEETEC
EVGPDGVRRN CTFQRLECVT NWICGMLHFT IVHGKTFELN CLSSDILEKG QEAFRFTWRL
ARGIISTNDE LFRPFRANSP FIGFKPAYEY NAGTYRCDVQ LLKNLKFVKR LYFGLRVLPP
KLVNLNFQQS LTEDQKLIDK GWEVNLDNGS KPHLPVWQRK VTSALGIGIV AGVVGGVLVS
VAVFKALGGT DGSGGRTRL
