ID   TMM81_RAT               Reviewed;         262 AA.
AC   Q6AXW8;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Transmembrane protein 81;
DE   Flags: Precursor;
GN   Name=Tmem81;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; BC079284; AAH79284.1; -; mRNA.
DR   RefSeq; NP_001017490.1; NM_001017490.1.
DR   AlphaFoldDB; Q6AXW8; -.
DR   STRING; 10116.ENSRNOP00000034105; -.
DR   GlyGen; Q6AXW8; 2 sites.
DR   PaxDb; Q6AXW8; -.
DR   Ensembl; ENSRNOT00000035335; ENSRNOP00000034105; ENSRNOG00000028752.
DR   GeneID; 498229; -.
DR   KEGG; rno:498229; -.
DR   UCSC; RGD:1561544; rat.
DR   CTD; 388730; -.
DR   RGD; 1561544; Tmem81.
DR   eggNOG; ENOG502RYDZ; Eukaryota.
DR   GeneTree; ENSGT00390000006349; -.
DR   HOGENOM; CLU_093881_0_0_1; -.
DR   InParanoid; Q6AXW8; -.
DR   OMA; NATTCTV; -.
DR   OrthoDB; 1256219at2759; -.
DR   PhylomeDB; Q6AXW8; -.
DR   TreeFam; TF333177; -.
DR   PRO; PR:Q6AXW8; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000028752; Expressed in testis and 19 other tissues.
DR   Genevisible; Q6AXW8; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR039293; TMEM81.
DR   PANTHER; PTHR35670; PTHR35670; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..262
FT                   /note="Transmembrane protein 81"
FT                   /id="PRO_0000287878"
FT   TOPO_DOM        31..225
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247..262
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          83..171
FT                   /note="Ig-like"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        211
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        104..160
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   262 AA;  28886 MW;  C381008A17E3603C CRC64;
     MKAVATVFIC GSLVLITYLP LVVTSPQTLA IPEKLRQAVG RVVVNATACS VTCGLGYKEE
     TSCEVGPDGV RRDCRSQRLE CLTNWICGML HFTIIQRQQF ELNCLSSDIL TKGQEAFRFT
     WKLARGIIST NDELFKPFRA NSPFLRFKPA YESDSGTYRC DVQQLKNLKL VKRLYFGLRV
     LPPKLVNLNF QQSLTEDQKL AEEGWEVHLD NQSQPHLPGW RKKVSLALGV GIAAGVVGGV
     LVNVALCRVL GGTGGNGNLS SL