TMM82_HUMAN
ID TMM82_HUMAN Reviewed; 343 AA.
AC A0PJX8; B2RP27; Q5VVD4;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Transmembrane protein 82;
GN Name=TMEM82;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TMEM82 family. {ECO:0000305}.
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DR EMBL; AL450998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC127706; AAI27707.1; -; mRNA.
DR EMBL; BC127707; AAI27708.1; -; mRNA.
DR EMBL; BC137239; AAI37240.1; -; mRNA.
DR EMBL; BC137240; AAI37241.1; -; mRNA.
DR CCDS; CCDS30608.1; -.
DR RefSeq; NP_001013663.1; NM_001013641.2.
DR AlphaFoldDB; A0PJX8; -.
DR BioGRID; 132766; 4.
DR IntAct; A0PJX8; 1.
DR STRING; 9606.ENSP00000364938; -.
DR PhosphoSitePlus; A0PJX8; -.
DR BioMuta; TMEM82; -.
DR MassIVE; A0PJX8; -.
DR PaxDb; A0PJX8; -.
DR PeptideAtlas; A0PJX8; -.
DR PRIDE; A0PJX8; -.
DR ProteomicsDB; 70; -.
DR Antibodypedia; 28976; 61 antibodies from 18 providers.
DR DNASU; 388595; -.
DR Ensembl; ENST00000375782.2; ENSP00000364938.1; ENSG00000162460.7.
DR GeneID; 388595; -.
DR KEGG; hsa:388595; -.
DR MANE-Select; ENST00000375782.2; ENSP00000364938.1; NM_001013641.3; NP_001013663.1.
DR UCSC; uc001axc.5; human.
DR CTD; 388595; -.
DR DisGeNET; 388595; -.
DR GeneCards; TMEM82; -.
DR HGNC; HGNC:32350; TMEM82.
DR HPA; ENSG00000162460; Tissue enhanced (intestine, kidney, liver).
DR neXtProt; NX_A0PJX8; -.
DR OpenTargets; ENSG00000162460; -.
DR PharmGKB; PA162406636; -.
DR VEuPathDB; HostDB:ENSG00000162460; -.
DR eggNOG; ENOG502QVH3; Eukaryota.
DR GeneTree; ENSGT00500000045021; -.
DR HOGENOM; CLU_078402_0_0_1; -.
DR InParanoid; A0PJX8; -.
DR OMA; SEAMRFW; -.
DR OrthoDB; 1173079at2759; -.
DR PhylomeDB; A0PJX8; -.
DR TreeFam; TF332112; -.
DR PathwayCommons; A0PJX8; -.
DR SignaLink; A0PJX8; -.
DR BioGRID-ORCS; 388595; 104 hits in 1015 CRISPR screens.
DR GenomeRNAi; 388595; -.
DR Pharos; A0PJX8; Tdark.
DR PRO; PR:A0PJX8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; A0PJX8; protein.
DR Bgee; ENSG00000162460; Expressed in right lobe of liver and 38 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031648; TMEM82.
DR PANTHER; PTHR35257; PTHR35257; 1.
DR Pfam; PF15816; TMEM82; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..343
FT /note="Transmembrane protein 82"
FT /id="PRO_0000309236"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 320..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 284
FT /note="R -> H (in dbSNP:rs11580250)"
FT /id="VAR_036917"
FT CONFLICT 308
FT /note="L -> IW (in Ref. 2; AAI27708)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 343 AA; 37222 MW; 1A3B2FE31D0394EC CRC64;
MFSLPSLPSW LPGLPSLEWG SSLLDSLLQG LIGALGVLVL NSLLKVYFFV GCANDPQRRP
EKERLRAQWA SLETVHLAGL ALFLTVVGSR VAALVVLEFS LRAVSTLLSL GKGSQGAAER
LQLYLLCQYS LGCGLTCGLS FLQEGAPHRT LNLLLSLGLA TLLGLGARRL HRHVCRLYEL
HSSQRYCGVC LGLLAHAHGL PQLLGRALAI AFAVGDLAAV ALINQDFLTT SEAMRFWTPL
TICYTLLVIY MQEEQRQHPG LQSQVQTVLV RMGGLFVLLL TVGRWLDLLG ILVSLLGELW
CLVGVRTLLD LCQIQDFPSQ RPPVSTPSQP LPSAPQSQSS APS
