ID   BTBDA_PONAB             Reviewed;         475 AA.
AC   Q5R585;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=BTB/POZ domain-containing protein 10;
DE   AltName: Full=Glucose metabolism-related protein 1;
GN   Name=BTBD10; Synonyms=GMRP1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a major role as an activator of AKT family members by
CC       inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs
CC       activated. Plays a role in preventing motor neuronal death and in
CC       accelerating the growth of pancreatic beta cells.
CC       {ECO:0000250|UniProtKB:Q80X66}.
CC   -!- SUBUNIT: Interacts (via C-terminal 330-amino-acid region) with AKT1;
CC       AKT2 and AKT3. Interacts with PPP2CA and PPP1CA.
CC       {ECO:0000250|UniProtKB:Q80X66}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BSF8}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q80X66}. Note=Colocalizes with KCTD20 in
CC       filamentous structures. {ECO:0000250|UniProtKB:Q80X66}.
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DR   EMBL; CR860979; CAH93081.1; -; mRNA.
DR   RefSeq; NP_001127627.1; NM_001134155.1.
DR   AlphaFoldDB; Q5R585; -.
DR   SMR; Q5R585; -.
DR   STRING; 9601.ENSPPYP00000003985; -.
DR   GeneID; 100174706; -.
DR   KEGG; pon:100174706; -.
DR   CTD; 84280; -.
DR   eggNOG; KOG3840; Eukaryota.
DR   InParanoid; Q5R585; -.
DR   OrthoDB; 390051at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:1901215; P:negative regulation of neuron death; ISS:UniProtKB.
DR   GO; GO:0042327; P:positive regulation of phosphorylation; ISS:UniProtKB.
DR   GO; GO:0044342; P:type B pancreatic cell proliferation; ISS:UniProtKB.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR039886; BTBD10/KCTD20.
DR   InterPro; IPR039885; BTBD10/KCTD20_BTB/POZ.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR21637; PTHR21637; 1.
DR   Pfam; PF16017; BTB_3; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..475
FT                   /note="BTB/POZ domain-containing protein 10"
FT                   /id="PRO_0000228987"
FT   DOMAIN          167..241
FT                   /note="BTB"
FT   REGION          1..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          146..475
FT                   /note="Interaction with AKT family members"
FT                   /evidence="ECO:0000250|UniProtKB:Q80X66"
FT   REGION          456..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..143
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   475 AA;  53749 MW;  0D7303891EAA33A6 CRC64;
     MAGRPHPYDG NSSDPENWDR KLHSRPRKLY KHSSTSSRIA KGGVDHTKMS LHGASGGHER
     SRDRRRSSDR SRDSSHERTE SQLTPCIRNV TSPTRQHHVE REKDHSSSRP SSPRPQKASP
     NGSISSAGNS SRNSSQSSSD GSCKTAGEMV FVYENAKEGA RNIRTSERVT LIVDNTRFVV
     DPSIFTAQPN TMLGRMFGSG REHNFTRPNE KGEYEVAEGI GSTVFRAILD YYKTGIIRCP
     DGISIPELRE ACDYLCISFE YSTIKCRDLS ALMHELSNDG ARRQFEFYLE EMILPLMVAS
     AQSGERECHI VVLTDDDVVD WDEEYPPQMG EEYSQIIYST KLYRFFKYIE NRDVAKSVLK
     ERGLKKIRLG IEGYPTYKEK VKKRPGGRPE VIYNYVQRPF IRMSWEKEEG KSRHVDFQCV
     KSKSITNLAA AAADIPQDQL VVMHPTPQVD ELDILPIHPP SGNSDLDPDA QNPTL