ID   TMM82_MOUSE             Reviewed;         356 AA.
AC   Q8R115; A2ADF5;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Transmembrane protein 82;
GN   Name=Tmem82;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, and Liver;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TMEM82 family. {ECO:0000305}.
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DR   EMBL; AL670446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC025833; AAH25833.1; -; mRNA.
DR   CCDS; CCDS18877.1; -.
DR   RefSeq; NP_666099.2; NM_145987.2.
DR   AlphaFoldDB; Q8R115; -.
DR   STRING; 10090.ENSMUSP00000058412; -.
DR   iPTMnet; Q8R115; -.
DR   PhosphoSitePlus; Q8R115; -.
DR   PaxDb; Q8R115; -.
DR   PRIDE; Q8R115; -.
DR   ProteomicsDB; 259135; -.
DR   Antibodypedia; 28976; 61 antibodies from 18 providers.
DR   Ensembl; ENSMUST00000053263; ENSMUSP00000058412; ENSMUSG00000043085.
DR   GeneID; 213989; -.
DR   KEGG; mmu:213989; -.
DR   UCSC; uc008vou.1; mouse.
DR   CTD; 388595; -.
DR   MGI; MGI:2384869; Tmem82.
DR   VEuPathDB; HostDB:ENSMUSG00000043085; -.
DR   eggNOG; ENOG502QVH3; Eukaryota.
DR   GeneTree; ENSGT00500000045021; -.
DR   HOGENOM; CLU_078402_0_0_1; -.
DR   InParanoid; Q8R115; -.
DR   OMA; SEAMRFW; -.
DR   OrthoDB; 1173079at2759; -.
DR   PhylomeDB; Q8R115; -.
DR   TreeFam; TF332112; -.
DR   BioGRID-ORCS; 213989; 6 hits in 73 CRISPR screens.
DR   PRO; PR:Q8R115; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q8R115; protein.
DR   Bgee; ENSMUSG00000043085; Expressed in small intestine Peyer's patch and 44 other tissues.
DR   ExpressionAtlas; Q8R115; baseline and differential.
DR   Genevisible; Q8R115; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR031648; TMEM82.
DR   PANTHER; PTHR35257; PTHR35257; 1.
DR   Pfam; PF15816; TMEM82; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..356
FT                   /note="Transmembrane protein 82"
FT                   /id="PRO_0000309237"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          331..356
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..356
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        255
FT                   /note="W -> R (in Ref. 2; AAH25833)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   356 AA;  38882 MW;  4CE83FDB1C67358C CRC64;
     MFSLPSLSSW LPSLPSFEWG SSLFDSLLQG LIGALGVSVL NSLLKVYFFV ACVNDPQRQP
     QKQRLSAQWA SLEMLHLAGL TLFLTLIGSR VAALVVLEFS LRAVSTLLSL GKGSGNKERL
     QLFLVCQFSL GCGLSCGLSF LQEGAPHRSL NLLLSLGLAV LLALGARRLT RHICSLYELH
     SSQRYCGVCL GLLASQHGMP RLLSRTLTVA FAVSDLAAVA LINKDFLSSS EAVRFWTPLT
     ICYTLLVIYM QEEQWQHRFS LQGQVQTVLV RMGGLFLLLM TVGRWLDLLS IFFSLLGELW
     CLAGIRALID LCQIQGFPPQ RPTVTAAVTA EGESGWTDPC EPRPSTPAPA RSAVPS