ID   TMM88_BOVIN             Reviewed;         159 AA.
AC   A5D7M7;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Transmembrane protein 88;
GN   Name=TMEM88;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits the Wnt/beta-catenin signaling pathway. Crucial for
CC       heart development and acts downstream of GATA factors in the pre-
CC       cardiac mesoderm to specify lineage commitment of cardiomyocyte
CC       development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts (via C-terminus) with DVL1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the TMEM88 family. {ECO:0000305}.
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DR   EMBL; BC140617; AAI40618.1; -; mRNA.
DR   RefSeq; NP_001091848.1; NM_001098378.2.
DR   AlphaFoldDB; A5D7M7; -.
DR   STRING; 9913.ENSBTAP00000019555; -.
DR   PaxDb; A5D7M7; -.
DR   Ensembl; ENSBTAT00000019555; ENSBTAP00000019555; ENSBTAG00000014693.
DR   GeneID; 507172; -.
DR   KEGG; bta:507172; -.
DR   CTD; 92162; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014693; -.
DR   VGNC; VGNC:36120; TMEM88.
DR   eggNOG; ENOG502S52P; Eukaryota.
DR   GeneTree; ENSGT00940000162021; -.
DR   HOGENOM; CLU_105667_1_0_1; -.
DR   InParanoid; A5D7M7; -.
DR   OMA; CWACAEL; -.
DR   OrthoDB; 1391325at2759; -.
DR   TreeFam; TF332743; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000014693; Expressed in tongue muscle and 103 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0030165; F:PDZ domain binding; IBA:GO_Central.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR033355; TMEM88.
DR   InterPro; IPR033354; TMEM88A.
DR   PANTHER; PTHR28628; PTHR28628; 1.
DR   PANTHER; PTHR28628:SF3; PTHR28628:SF3; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Developmental protein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Wnt signaling pathway.
FT   CHAIN           1..159
FT                   /note="Transmembrane protein 88"
FT                   /id="PRO_0000346448"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          135..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   159 AA;  17187 MW;  CBEA842FC69220BB CRC64;
     MADVPGAQRP VPGGGPEPRD PLDCWACAVL VTAQNLLVAA FNLLLLALVL GTILLPAVTM
     LGFGFLCHSQ FLRSQAPPCT AHLRDPGFTA LLVTGFLLLV PLLVLALASY RRLCLRLRLA
     DCLVPYSRAL YRRRRNPQPR PARSSPGPQV APTSGKVWV