TMM88_MOUSE
ID TMM88_MOUSE Reviewed; 159 AA.
AC Q9D0N8; Q497Z2; Q8BRC2;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Transmembrane protein 88;
GN Name=Tmem88;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis, and Thyroid;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thyroid;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibits the Wnt/beta-catenin signaling pathway. Crucial for
CC heart development and acts downstream of GATA factors in the pre-
CC cardiac mesoderm to specify lineage commitment of cardiomyocyte
CC development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts (via C-terminus) with DVL1. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9D0N8; P51141: Dvl1; NbExp=2; IntAct=EBI-6136970, EBI-1538407;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein.
CC -!- SIMILARITY: Belongs to the TMEM88 family. {ECO:0000305}.
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DR EMBL; AK045149; BAC32239.1; -; mRNA.
DR EMBL; AK011240; BAB27488.1; -; mRNA.
DR EMBL; AK161789; BAE36575.1; -; mRNA.
DR EMBL; AL596125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC100316; AAI00317.1; -; mRNA.
DR EMBL; BC120912; AAI20913.1; -; mRNA.
DR CCDS; CCDS24894.1; -.
DR RefSeq; NP_080191.3; NM_025915.4.
DR AlphaFoldDB; Q9D0N8; -.
DR IntAct; Q9D0N8; 1.
DR STRING; 10090.ENSMUSP00000055528; -.
DR iPTMnet; Q9D0N8; -.
DR PhosphoSitePlus; Q9D0N8; -.
DR SwissPalm; Q9D0N8; -.
DR PaxDb; Q9D0N8; -.
DR PRIDE; Q9D0N8; -.
DR ProteomicsDB; 259432; -.
DR Antibodypedia; 58901; 44 antibodies from 17 providers.
DR DNASU; 67020; -.
DR Ensembl; ENSMUST00000050140; ENSMUSP00000055528; ENSMUSG00000045377.
DR GeneID; 67020; -.
DR KEGG; mmu:67020; -.
DR UCSC; uc007jqc.2; mouse.
DR CTD; 92162; -.
DR MGI; MGI:1914270; Tmem88.
DR VEuPathDB; HostDB:ENSMUSG00000045377; -.
DR eggNOG; ENOG502S52P; Eukaryota.
DR GeneTree; ENSGT00940000162021; -.
DR HOGENOM; CLU_105667_1_0_1; -.
DR InParanoid; Q9D0N8; -.
DR OMA; CWACAEL; -.
DR OrthoDB; 1391325at2759; -.
DR PhylomeDB; Q9D0N8; -.
DR TreeFam; TF332743; -.
DR BioGRID-ORCS; 67020; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem88; mouse.
DR PRO; PR:Q9D0N8; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9D0N8; protein.
DR Bgee; ENSMUSG00000045377; Expressed in yolk sac and 60 other tissues.
DR Genevisible; Q9D0N8; MM.
DR GO; GO:0005829; C:cytosol; ISS:ParkinsonsUK-UCL.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:ParkinsonsUK-UCL.
DR GO; GO:0030165; F:PDZ domain binding; IDA:ParkinsonsUK-UCL.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:ParkinsonsUK-UCL.
DR GO; GO:0072659; P:protein localization to plasma membrane; ISS:ParkinsonsUK-UCL.
DR GO; GO:0050821; P:protein stabilization; ISS:ParkinsonsUK-UCL.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR033355; TMEM88.
DR InterPro; IPR033354; TMEM88A.
DR PANTHER; PTHR28628; PTHR28628; 1.
DR PANTHER; PTHR28628:SF3; PTHR28628:SF3; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Developmental protein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Wnt signaling pathway.
FT CHAIN 1..159
FT /note="Transmembrane protein 88"
FT /id="PRO_0000251708"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 64
FT /note="G -> S (in Ref. 1; BAC32239)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 159 AA; 17358 MW; 2988D626F2C13C36 CRC64;
MAEVPGAQRP VLAGGPEPRD PLDCWACAVL VTAQNLLVAV FNLLLLALVL GTILLPAVIM
LGFGFLCHSQ FLRSQAPLCT SHLRDPGFTA LLVTGFLLLV PLLVLALATY RRLCLRLRLA
DCLVPYSRAL YRRRRIPQPK QIPVSPGSRS VPTPGKVWV
