ID   TMM89_HUMAN             Reviewed;         159 AA.
AC   A2RUT3;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Transmembrane protein 89;
DE   Flags: Precursor;
GN   Name=TMEM89;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
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DR   EMBL; BC133034; AAI33035.1; -; mRNA.
DR   EMBL; BC133036; AAI33037.1; -; mRNA.
DR   CCDS; CCDS33751.1; -.
DR   RefSeq; NP_001008270.1; NM_001008269.1.
DR   AlphaFoldDB; A2RUT3; -.
DR   SMR; A2RUT3; -.
DR   BioGRID; 137028; 2.
DR   IntAct; A2RUT3; 1.
DR   STRING; 9606.ENSP00000329557; -.
DR   PhosphoSitePlus; A2RUT3; -.
DR   BioMuta; TMEM89; -.
DR   MassIVE; A2RUT3; -.
DR   PaxDb; A2RUT3; -.
DR   PeptideAtlas; A2RUT3; -.
DR   PRIDE; A2RUT3; -.
DR   ProteomicsDB; 524; -.
DR   Antibodypedia; 66345; 6 antibodies from 6 providers.
DR   DNASU; 440955; -.
DR   Ensembl; ENST00000330862.4; ENSP00000329557.3; ENSG00000183396.4.
DR   GeneID; 440955; -.
DR   KEGG; hsa:440955; -.
DR   MANE-Select; ENST00000330862.4; ENSP00000329557.3; NM_001008269.3; NP_001008270.1.
DR   UCSC; uc011bbo.3; human.
DR   CTD; 440955; -.
DR   GeneCards; TMEM89; -.
DR   HGNC; HGNC:32372; TMEM89.
DR   HPA; ENSG00000183396; Tissue enriched (testis).
DR   neXtProt; NX_A2RUT3; -.
DR   PharmGKB; PA142670742; -.
DR   VEuPathDB; HostDB:ENSG00000183396; -.
DR   eggNOG; ENOG502TDUC; Eukaryota.
DR   GeneTree; ENSGT00390000005336; -.
DR   HOGENOM; CLU_1859782_0_0_1; -.
DR   InParanoid; A2RUT3; -.
DR   OMA; CPGHWMG; -.
DR   OrthoDB; 1413701at2759; -.
DR   PhylomeDB; A2RUT3; -.
DR   TreeFam; TF336927; -.
DR   PathwayCommons; A2RUT3; -.
DR   SignaLink; A2RUT3; -.
DR   BioGRID-ORCS; 440955; 7 hits in 1062 CRISPR screens.
DR   GenomeRNAi; 440955; -.
DR   Pharos; A2RUT3; Tdark.
DR   PRO; PR:A2RUT3; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; A2RUT3; protein.
DR   Bgee; ENSG00000183396; Expressed in left testis and 71 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR   InterPro; IPR028069; TMEM89.
DR   PANTHER; PTHR37869; PTHR37869; 1.
DR   Pfam; PF15098; TMEM89; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..159
FT                   /note="Transmembrane protein 89"
FT                   /id="PRO_0000290067"
FT   TOPO_DOM        25..63
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..159
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          91..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         61
FT                   /note="P -> T (in dbSNP:rs9834639)"
FT                   /id="VAR_051450"
SQ   SEQUENCE   159 AA;  17572 MW;  D6B70549CE50DD13 CRC64;
     MLHVLASLPL LLLLVTSAST HAWSRPLWYQ VGLDLQPWGC QPKSVEGCRG GLSCPGYWLG
     PGASRIYPVA AVMITTTMLM ICRKILQGRR RSQATKGEHP QVTTEPCGPW KRRAPISDHT
     LLRGVLHMLD ALLVHIEGHL RHLATQRQIQ IKGTSTQSG