TMM89_MOUSE
ID TMM89_MOUSE Reviewed; 169 AA.
AC Q9DA04; Q2M2L9;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Transmembrane protein 89;
DE Flags: Precursor;
GN Name=Tmem89;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9DA04-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DA04-2; Sequence=VSP_026116, VSP_026117;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB24511.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK006292; BAB24511.1; ALT_FRAME; mRNA.
DR EMBL; BC111913; AAI11914.1; -; mRNA.
DR CCDS; CCDS52928.1; -. [Q9DA04-1]
DR RefSeq; NP_081342.1; NM_027066.1. [Q9DA04-1]
DR AlphaFoldDB; Q9DA04; -.
DR iPTMnet; Q9DA04; -.
DR PhosphoSitePlus; Q9DA04; -.
DR PaxDb; Q9DA04; -.
DR PRIDE; Q9DA04; -.
DR ProteomicsDB; 259136; -. [Q9DA04-1]
DR ProteomicsDB; 259137; -. [Q9DA04-2]
DR Antibodypedia; 66345; 6 antibodies from 6 providers.
DR Ensembl; ENSMUST00000026744; ENSMUSP00000026744; ENSMUSG00000025652. [Q9DA04-1]
DR Ensembl; ENSMUST00000192852; ENSMUSP00000142016; ENSMUSG00000025652. [Q9DA04-2]
DR GeneID; 69384; -.
DR KEGG; mmu:69384; -.
DR UCSC; uc009rrf.1; mouse. [Q9DA04-1]
DR CTD; 440955; -.
DR MGI; MGI:1916634; Tmem89.
DR VEuPathDB; HostDB:ENSMUSG00000025652; -.
DR eggNOG; ENOG502TDUC; Eukaryota.
DR GeneTree; ENSGT00390000005336; -.
DR HOGENOM; CLU_1859782_0_0_1; -.
DR InParanoid; Q9DA04; -.
DR OMA; CPGHWMG; -.
DR OrthoDB; 1413701at2759; -.
DR PhylomeDB; Q9DA04; -.
DR TreeFam; TF336927; -.
DR BioGRID-ORCS; 69384; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9DA04; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9DA04; protein.
DR Bgee; ENSMUSG00000025652; Expressed in spermatid and 16 other tissues.
DR Genevisible; Q9DA04; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR028069; TMEM89.
DR PANTHER; PTHR37869; PTHR37869; 2.
DR Pfam; PF15098; TMEM89; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..169
FT /note="Transmembrane protein 89"
FT /id="PRO_0000290068"
FT TOPO_DOM 23..75
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 109..140
FT /note="LPAVTSSSGKHWKEQPTVSDRTLVLRVLHMLD -> VSTAPLCPLQFLLLLM
FT PPGPCLPLNLLPITLA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026116"
FT VAR_SEQ 141..169
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_026117"
SQ SEQUENCE 169 AA; 18598 MW; 944F8B1B568AECD2 CRC64;
MLYTLLLVPS LFLLVMPVPS QGWSRPLWYQ VGLDLQPWGC QPNSPDIWGC QPNSLDSCKN
SLGCPGYWLG LGGNRIYPVA GVTITTTMLL VVSRVIVHRW RAKVAKGQLP AVTSSSGKHW
KEQPTVSDRT LVLRVLHMLD AILLHIEGHL QGLASQQQIQ IKGSPPQSG
