TMM91_HUMAN
ID TMM91_HUMAN Reviewed; 172 AA.
AC Q6ZNR0; C9J9D1; C9JZ62; C9K046; Q6P434;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transmembrane protein 91;
DE AltName: Full=Dispanin subfamily C member 3;
DE Short=DSPC3;
GN Name=TMEM91;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RX PubMed=8889548; DOI=10.1101/gr.6.9.791;
RA Bonaldo M.F., Lennon G., Soares M.B.;
RT "Normalization and subtraction: two approaches to facilitate gene
RT discovery.";
RL Genome Res. 6:791-806(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RA Ebert L., Heil O., Hennig S., Neubert P., Partsch E., Peters M.,
RA Radelof U., Schneider D., Korn B.;
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Leiomyosarcoma, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP GENE FAMILY.
RX PubMed=22363774; DOI=10.1371/journal.pone.0031961;
RA Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
RT "The dispanins: a novel gene family of ancient origin that contains 14
RT human members.";
RL PLoS ONE 7:E31961-E31961(2012).
CC -!- INTERACTION:
CC Q6ZNR0-2; O75841: UPK1B; NbExp=3; IntAct=EBI-13345425, EBI-12237619;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q6ZNR0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZNR0-2; Sequence=VSP_042819;
CC Name=3;
CC IsoId=Q6ZNR0-3; Sequence=VSP_045717;
CC Name=4;
CC IsoId=Q6ZNR0-4; Sequence=VSP_047211;
CC Name=5;
CC IsoId=Q6ZNR0-5; Sequence=VSP_047212;
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BM931402; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BM931402; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BX090160; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK130820; BAC85439.1; -; mRNA.
DR EMBL; AC011462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471126; EAW57037.1; -; Genomic_DNA.
DR EMBL; BC063705; AAH63705.1; -; mRNA.
DR EMBL; BF684543; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS42571.1; -. [Q6ZNR0-1]
DR CCDS; CCDS42572.1; -. [Q6ZNR0-2]
DR CCDS; CCDS46082.1; -. [Q6ZNR0-5]
DR CCDS; CCDS46083.1; -. [Q6ZNR0-3]
DR CCDS; CCDS46084.1; -. [Q6ZNR0-4]
DR RefSeq; NP_001036060.1; NM_001042595.2. [Q6ZNR0-2]
DR RefSeq; NP_001092291.1; NM_001098821.1. [Q6ZNR0-1]
DR RefSeq; NP_001092292.1; NM_001098822.1. [Q6ZNR0-5]
DR RefSeq; NP_001092293.1; NM_001098823.1. [Q6ZNR0-3]
DR RefSeq; NP_001092294.1; NM_001098824.1. [Q6ZNR0-4]
DR RefSeq; NP_001092295.1; NM_001098825.1. [Q6ZNR0-5]
DR AlphaFoldDB; Q6ZNR0; -.
DR BioGRID; 535010; 2.
DR IntAct; Q6ZNR0; 1.
DR STRING; 9606.ENSP00000375859; -.
DR TCDB; 8.A.58.2.3; the dispanin (dispanin) family.
DR iPTMnet; Q6ZNR0; -.
DR PhosphoSitePlus; Q6ZNR0; -.
DR BioMuta; TMEM91; -.
DR DMDM; 55976711; -.
DR PaxDb; Q6ZNR0; -.
DR PeptideAtlas; Q6ZNR0; -.
DR PRIDE; Q6ZNR0; -.
DR Antibodypedia; 35353; 78 antibodies from 15 providers.
DR DNASU; 641649; -.
DR Ensembl; ENST00000356385.8; ENSP00000348750.4; ENSG00000142046.15. [Q6ZNR0-2]
DR Ensembl; ENST00000392002.7; ENSP00000375859.1; ENSG00000142046.15. [Q6ZNR0-1]
DR Ensembl; ENST00000413014.6; ENSP00000413192.2; ENSG00000142046.15. [Q6ZNR0-5]
DR Ensembl; ENST00000436170.6; ENSP00000407003.2; ENSG00000142046.15. [Q6ZNR0-4]
DR Ensembl; ENST00000447302.6; ENSP00000405647.2; ENSG00000142046.15. [Q6ZNR0-3]
DR Ensembl; ENST00000544232.5; ENSP00000437779.1; ENSG00000142046.15. [Q6ZNR0-5]
DR GeneID; 641649; -.
DR KEGG; hsa:641649; -.
DR MANE-Select; ENST00000392002.7; ENSP00000375859.1; NM_001098821.2; NP_001092291.1.
DR UCSC; uc002oqk.5; human. [Q6ZNR0-1]
DR CTD; 641649; -.
DR DisGeNET; 641649; -.
DR GeneCards; TMEM91; -.
DR HGNC; HGNC:32393; TMEM91.
DR HPA; ENSG00000142046; Low tissue specificity.
DR MIM; 618294; gene.
DR neXtProt; NX_Q6ZNR0; -.
DR OpenTargets; ENSG00000142046; -.
DR PharmGKB; PA142670743; -.
DR VEuPathDB; HostDB:ENSG00000142046; -.
DR eggNOG; ENOG502TEEM; Eukaryota.
DR GeneTree; ENSGT00950000183147; -.
DR HOGENOM; CLU_094250_1_0_1; -.
DR InParanoid; Q6ZNR0; -.
DR OMA; GLCTYAA; -.
DR OrthoDB; 1273993at2759; -.
DR PhylomeDB; Q6ZNR0; -.
DR TreeFam; TF331357; -.
DR PathwayCommons; Q6ZNR0; -.
DR SignaLink; Q6ZNR0; -.
DR BioGRID-ORCS; 641649; 12 hits in 1082 CRISPR screens.
DR ChiTaRS; TMEM91; human.
DR GenomeRNAi; 641649; -.
DR Pharos; Q6ZNR0; Tdark.
DR PRO; PR:Q6ZNR0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6ZNR0; protein.
DR Bgee; ENSG00000142046; Expressed in nucleus accumbens and 169 other tissues.
DR ExpressionAtlas; Q6ZNR0; baseline and differential.
DR Genevisible; Q6ZNR0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR Pfam; PF04505; CD225; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..172
FT /note="Transmembrane protein 91"
FT /id="PRO_0000135699"
FT TOPO_DOM 1..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..172
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 55..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 121..172
FT /note="TNKAWAKGDIQGAGAASRRAFLLGVLAVGLGVCTYAAALVTLAAYLASRDPP
FT -> HPQCLTYSRCYVSAFGIHA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_042819"
FT VAR_SEQ 121..172
FT /note="TNKAWAKGDIQGAGAASRRAFLLGVLAVGLGVCTYAAALVTLAAYLASRDPP
FT -> LPLQPSL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045717"
FT VAR_SEQ 121..172
FT /note="TNKAWAKGDIQGAGAASRRAFLLGVLAVGLGVCTYAAALVTLAAYLASRDPP
FT -> PSL (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:8889548"
FT /id="VSP_047211"
FT VAR_SEQ 122..171
FT /note="NKAWAKGDIQGAGAASRRAFLLGVLAVGLGVCTYAAALVTLAAYLASRDP
FT -> RPSCPYSPHCE (in isoform 5)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_047212"
FT CONFLICT 1
FT /note="M -> L (in Ref. 2; BX090160)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="A -> G (in Ref. 1; BM931402)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 172 AA; 18162 MW; 5F8CAAC51D662BD3 CRC64;
MDSPSLRELQ QPLLEGTECE TPAQKPGRHE LGSPLREIAF AESLRGLQFL SPPLPSVSAG
LGEPRPPDVE DMSSSDSDSD WDGGSRLSPF LPHDHLGLAV FSMLCCFWPV GIAAFCLAQK
TNKAWAKGDI QGAGAASRRA FLLGVLAVGL GVCTYAAALV TLAAYLASRD PP
