TMM91_MOUSE
ID TMM91_MOUSE Reviewed; 172 AA.
AC Q8C581;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Transmembrane protein 91;
DE AltName: Full=Dispanin subfamily C member 3;
DE Short=DSPC3;
DE AltName: Full=Synapse differentiation-induced protein 3;
GN Name=Tmem91; Synonyms=SynDIG3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP GENE FAMILY.
RX PubMed=22363774; DOI=10.1371/journal.pone.0031961;
RA Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
RT "The dispanins: a novel gene family of ancient origin that contains 14
RT human members.";
RL PLoS ONE 7:E31961-E31961(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
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DR EMBL; AK079312; BAC37604.1; -; mRNA.
DR EMBL; BC058996; AAH58996.1; -; mRNA.
DR CCDS; CCDS39840.1; -.
DR RefSeq; NP_001277426.1; NM_001290497.1.
DR RefSeq; NP_001277427.1; NM_001290498.1.
DR RefSeq; NP_796076.1; NM_177102.4.
DR RefSeq; XP_006540130.1; XM_006540067.3.
DR RefSeq; XP_006540131.1; XM_006540068.3.
DR RefSeq; XP_006540132.1; XM_006540069.3.
DR AlphaFoldDB; Q8C581; -.
DR STRING; 10090.ENSMUSP00000078407; -.
DR iPTMnet; Q8C581; -.
DR PhosphoSitePlus; Q8C581; -.
DR PaxDb; Q8C581; -.
DR PRIDE; Q8C581; -.
DR Antibodypedia; 35353; 78 antibodies from 15 providers.
DR Ensembl; ENSMUST00000079439; ENSMUSP00000078407; ENSMUSG00000061702.
DR GeneID; 320208; -.
DR KEGG; mmu:320208; -.
DR UCSC; uc009ftk.2; mouse.
DR CTD; 641649; -.
DR MGI; MGI:2443589; Tmem91.
DR VEuPathDB; HostDB:ENSMUSG00000061702; -.
DR eggNOG; ENOG502TEEM; Eukaryota.
DR GeneTree; ENSGT00950000183147; -.
DR HOGENOM; CLU_094250_1_0_1; -.
DR InParanoid; Q8C581; -.
DR OMA; GLCTYAA; -.
DR OrthoDB; 1273993at2759; -.
DR PhylomeDB; Q8C581; -.
DR TreeFam; TF331357; -.
DR BioGRID-ORCS; 320208; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q8C581; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8C581; protein.
DR Bgee; ENSMUSG00000061702; Expressed in embryonic brain and 80 other tissues.
DR ExpressionAtlas; Q8C581; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
DR InterPro; IPR007593; CD225/Dispanin_fam.
DR Pfam; PF04505; CD225; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..172
FT /note="Transmembrane protein 91"
FT /id="PRO_0000135700"
FT TOPO_DOM 1..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..172
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 60..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 172 AA; 18085 MW; F4E8A2F173DAAB6A CRC64;
MDNSSIQELQ QPLLPSITCD LLAPRSEKPE LGTPFPETAF AESPRGWQLL LPPLPSVSAG
LGEPETPDFE DTLSSDSDSD DDGGDRLSPL LPHDHLGLAV FSVLCCFWPV GIAAFCLAHK
TNKAWAKGDV QGAGAASRRA FLLGVLAVGL GLCTYAAALV TLAAYLASRD PP
