TMM92_HUMAN
ID TMM92_HUMAN Reviewed; 159 AA.
AC Q6UXU6; Q8NBF0;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Transmembrane protein 92;
DE Flags: Precursor;
GN Name=TMEM92; ORFNames=UNQ5801/PRO19608;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-90.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-90.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6UXU6; Q96Q80: DERL3; NbExp=3; IntAct=EBI-10975829, EBI-12831318;
CC Q6UXU6; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-10975829, EBI-10244780;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
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DR EMBL; AY358204; AAQ88571.1; -; mRNA.
DR EMBL; AK090637; BAC03495.1; -; mRNA.
DR EMBL; BC064507; AAH64507.1; -; mRNA.
DR CCDS; CCDS11562.1; -.
DR RefSeq; NP_001161687.1; NM_001168215.1.
DR RefSeq; NP_694961.2; NM_153229.2.
DR AlphaFoldDB; Q6UXU6; -.
DR BioGRID; 127818; 17.
DR IntAct; Q6UXU6; 15.
DR STRING; 9606.ENSP00000300433; -.
DR BioMuta; TMEM92; -.
DR DMDM; 74738274; -.
DR jPOST; Q6UXU6; -.
DR MassIVE; Q6UXU6; -.
DR MaxQB; Q6UXU6; -.
DR PaxDb; Q6UXU6; -.
DR PeptideAtlas; Q6UXU6; -.
DR PRIDE; Q6UXU6; -.
DR Antibodypedia; 68410; 10 antibodies from 5 providers.
DR DNASU; 162461; -.
DR Ensembl; ENST00000300433.7; ENSP00000300433.3; ENSG00000167105.8.
DR Ensembl; ENST00000507382.2; ENSP00000425144.1; ENSG00000167105.8.
DR GeneID; 162461; -.
DR KEGG; hsa:162461; -.
DR MANE-Select; ENST00000507382.2; ENSP00000425144.1; NM_153229.3; NP_694961.2.
DR UCSC; uc002iqn.2; human.
DR CTD; 162461; -.
DR DisGeNET; 162461; -.
DR GeneCards; TMEM92; -.
DR HGNC; HGNC:26579; TMEM92.
DR HPA; ENSG00000167105; Tissue enhanced (intestine, stomach).
DR MIM; 619604; gene.
DR neXtProt; NX_Q6UXU6; -.
DR OpenTargets; ENSG00000167105; -.
DR PharmGKB; PA142670744; -.
DR VEuPathDB; HostDB:ENSG00000167105; -.
DR eggNOG; ENOG502TG6F; Eukaryota.
DR GeneTree; ENSGT00390000014943; -.
DR HOGENOM; CLU_141701_0_0_1; -.
DR InParanoid; Q6UXU6; -.
DR OMA; QENEFFS; -.
DR OrthoDB; 1502903at2759; -.
DR PhylomeDB; Q6UXU6; -.
DR TreeFam; TF338534; -.
DR PathwayCommons; Q6UXU6; -.
DR SignaLink; Q6UXU6; -.
DR BioGRID-ORCS; 162461; 15 hits in 1037 CRISPR screens.
DR ChiTaRS; TMEM92; human.
DR GenomeRNAi; 162461; -.
DR Pharos; Q6UXU6; Tdark.
DR PRO; PR:Q6UXU6; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q6UXU6; protein.
DR Bgee; ENSG00000167105; Expressed in pancreatic ductal cell and 114 other tissues.
DR Genevisible; Q6UXU6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR021684; WBP1-like.
DR Pfam; PF11669; WBP-1; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..159
FT /note="Transmembrane protein 92"
FT /id="PRO_0000251709"
FT TOPO_DOM 27..57
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 122..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..143
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 4
FT /note="A -> T (in dbSNP:rs9894445)"
FT /id="VAR_061715"
FT VARIANT 90
FT /note="S -> N (in dbSNP:rs6504642)"
FT /id="VAR_027704"
FT VARIANT 90
FT /note="S -> T (in dbSNP:rs6504642)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_027703"
SQ SEQUENCE 159 AA; 17229 MW; 4C6C0678F3EA547C CRC64;
MSQAWVPGLA PTLLFSLLAG PQKIAAKCGL ILACPKGFKC CGDSCCQENE LFPGPVRIFV
IIFLVILSVF CICGLAKCFC RNCREPEPDS PVDCRGPLEL PSIIPPERVR VSLSAPPPPY
SEVILKPSLG PTPTEPPPPY SFRPEEYTGD QRGIDNPAF
