TMM92_MOUSE
ID TMM92_MOUSE Reviewed; 162 AA.
AC B7ZWI3; E9Q2K3; Q3UT21;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Transmembrane protein 92;
DE Flags: Precursor;
GN Name=Tmem92;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=B7ZWI3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=B7ZWI3-2; Sequence=VSP_042507;
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DR EMBL; AK139848; BAE24159.1; -; mRNA.
DR EMBL; AL645764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC172064; AAI72064.1; -; mRNA.
DR CCDS; CCDS36285.1; -. [B7ZWI3-2]
DR CCDS; CCDS48890.1; -. [B7ZWI3-1]
DR RefSeq; NP_001030068.1; NM_001034896.2. [B7ZWI3-2]
DR RefSeq; NP_001156644.1; NM_001163172.1. [B7ZWI3-1]
DR AlphaFoldDB; B7ZWI3; -.
DR STRING; 10090.ENSMUSP00000125159; -.
DR PaxDb; B7ZWI3; -.
DR PRIDE; B7ZWI3; -.
DR Antibodypedia; 68410; 10 antibodies from 5 providers.
DR Ensembl; ENSMUST00000100554; ENSMUSP00000128300; ENSMUSG00000075610. [B7ZWI3-2]
DR Ensembl; ENSMUST00000162809; ENSMUSP00000125159; ENSMUSG00000075610. [B7ZWI3-1]
DR GeneID; 544806; -.
DR KEGG; mmu:544806; -.
DR UCSC; uc007kzl.1; mouse. [B7ZWI3-2]
DR UCSC; uc029rno.1; mouse. [B7ZWI3-1]
DR CTD; 162461; -.
DR MGI; MGI:3034723; Tmem92.
DR VEuPathDB; HostDB:ENSMUSG00000075610; -.
DR eggNOG; ENOG502TG6F; Eukaryota.
DR GeneTree; ENSGT00390000014943; -.
DR HOGENOM; CLU_141701_0_0_1; -.
DR InParanoid; B7ZWI3; -.
DR OMA; QENEFFS; -.
DR OrthoDB; 1502903at2759; -.
DR TreeFam; TF338534; -.
DR BioGRID-ORCS; 544806; 0 hits in 72 CRISPR screens.
DR PRO; PR:B7ZWI3; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; B7ZWI3; protein.
DR Bgee; ENSMUSG00000075610; Expressed in animal zygote and 14 other tissues.
DR ExpressionAtlas; B7ZWI3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR021684; WBP1-like.
DR Pfam; PF11669; WBP-1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..162
FT /note="Transmembrane protein 92"
FT /id="PRO_0000416120"
FT TOPO_DOM 23..63
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..162
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 134..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 83..130
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_042507"
SQ SEQUENCE 162 AA; 18079 MW; C8399F19809FB143 CRC64;
MLDTWVWGTL TLTFGLLSSL QGVSFNETAN TCDILNCPKG FTCCVKECCP ERKVWDPAND
RFRFLVILAC IIFPILFICA LVSLFCPNCT ELQHDVRRVD HQTPIEPPSI APLESIWVTS
LDPPPPYSQV VQMTPPTEPP PPYSLRPEGP AGQMRGRAYA TL
