BTBDB_MOUSE
ID BTBDB_MOUSE Reviewed; 1109 AA.
AC Q6GQW0; Q6PCZ7; Q8CAD2; Q8CDA2; Q9D3B9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Ankyrin repeat and BTB/POZ domain-containing protein BTBD11;
DE AltName: Full=BTB/POZ domain-containing protein 11;
GN Name=Btbd11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 515-1109 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus, Medulla oblongata, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q6GQW0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6GQW0-2; Sequence=VSP_032805, VSP_032807;
CC Name=3;
CC IsoId=Q6GQW0-3; Sequence=VSP_032804;
CC Name=4;
CC IsoId=Q6GQW0-4; Sequence=VSP_032806, VSP_032808;
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DR EMBL; AK018115; BAB31077.1; -; mRNA.
DR EMBL; AK039038; BAC30216.1; -; mRNA.
DR EMBL; AK030864; BAC27162.1; -; mRNA.
DR EMBL; BC059036; AAH59036.1; -; mRNA.
DR EMBL; BC072592; AAH72592.1; -; mRNA.
DR EMBL; BC096535; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS24091.2; -. [Q6GQW0-1]
DR RefSeq; NP_001017525.1; NM_001017525.1.
DR RefSeq; NP_082985.2; NM_028709.2. [Q6GQW0-1]
DR AlphaFoldDB; Q6GQW0; -.
DR SMR; Q6GQW0; -.
DR BioGRID; 216418; 5.
DR IntAct; Q6GQW0; 2.
DR STRING; 10090.ENSMUSP00000100944; -.
DR iPTMnet; Q6GQW0; -.
DR PhosphoSitePlus; Q6GQW0; -.
DR EPD; Q6GQW0; -.
DR MaxQB; Q6GQW0; -.
DR PaxDb; Q6GQW0; -.
DR PeptideAtlas; Q6GQW0; -.
DR PRIDE; Q6GQW0; -.
DR ProteomicsDB; 265252; -. [Q6GQW0-1]
DR ProteomicsDB; 265253; -. [Q6GQW0-2]
DR ProteomicsDB; 265254; -. [Q6GQW0-3]
DR ProteomicsDB; 265255; -. [Q6GQW0-4]
DR Antibodypedia; 76946; 6 antibodies from 6 providers.
DR DNASU; 74007; -.
DR Ensembl; ENSMUST00000105307; ENSMUSP00000100944; ENSMUSG00000020042. [Q6GQW0-1]
DR GeneID; 74007; -.
DR KEGG; mmu:74007; -.
DR UCSC; uc007glg.2; mouse. [Q6GQW0-1]
DR UCSC; uc007gli.1; mouse. [Q6GQW0-3]
DR CTD; 121551; -.
DR MGI; MGI:1921257; Btbd11.
DR VEuPathDB; HostDB:ENSMUSG00000020042; -.
DR eggNOG; ENOG502QSQY; Eukaryota.
DR GeneTree; ENSGT00940000156419; -.
DR InParanoid; Q6GQW0; -.
DR OMA; GWPPLAD; -.
DR OrthoDB; 416322at2759; -.
DR PhylomeDB; Q6GQW0; -.
DR TreeFam; TF106437; -.
DR BioGRID-ORCS; 74007; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Btbd11; mouse.
DR PRO; PR:Q6GQW0; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q6GQW0; protein.
DR Bgee; ENSMUSG00000020042; Expressed in facial nucleus and 210 other tissues.
DR ExpressionAtlas; Q6GQW0; baseline and differential.
DR Genevisible; Q6GQW0; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0060395; P:SMAD protein signal transduction; IDA:MGI.
DR Gene3D; 1.10.20.10; -; 1.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF47113; SSF47113; 2.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..1109
FT /note="Ankyrin repeat and BTB/POZ domain-containing protein
FT BTBD11"
FT /id="PRO_0000328828"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 608..637
FT /note="ANK 1"
FT REPEAT 654..683
FT /note="ANK 2"
FT REPEAT 692..721
FT /note="ANK 3"
FT REPEAT 735..764
FT /note="ANK 4"
FT REPEAT 830..859
FT /note="ANK 5"
FT DOMAIN 928..994
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REGION 260..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..926
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032804"
FT VAR_SEQ 1..862
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032805"
FT VAR_SEQ 1..723
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032806"
FT VAR_SEQ 863..882
FT /note="TEELVTQGLPLMFEILKASK -> MVRTKDLLPEFENIDKGGWR (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032807"
FT VAR_SEQ 918..1109
FT /note="DPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSSKPTNDNTCIE
FT IGYVKYPIFQLVMQYLYYGGPESLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSIN
FT TDNCVDIYSHAKFLGVTELSAYCEGYFLKNMMVLIENEAFKQLLYDKNGEGAGQDVLQD
FT LQRTLAIRIQSIHLSSSKGSVV -> GEQWSGYTQAMAVGSGDGKEANMWNRYRM (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032808"
FT CONFLICT 515
FT /note="R -> G (in Ref. 1; BAC30216)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1109 AA; 121561 MW; 8BDB3F0A03E670AD CRC64;
MARRGKKPVV RTLEDLTLDS GYGGAADSVR SSNLSLCCSD SHPASPYGGS CWPPLADSMH
SRHNSFDTVN TALVEDSEGL DCAGQHCSRL LPDLDEVPWT LQELELLLLR SRDPRAGPAV
PGSLPKDALA KLSMLVSRAL VRIAKEAQRL SLRFAKCTKY EIQSAMEIVL SWGLAAHCTA
AALAALSLYN MSSAGGDRLG RGKSARCGLT FSVGRVYRWM VDSRVALRIH EHAAIYLTAC
MESLFRDIYS RVLASGLPRS CSGPGPGSSS GSGPGPGSGP GAPAADKERE TPGGGAASGG
PCSAASSASG GSSCCAPPAT AATAVPPTTA TAAVAANHHH HHHTLHEAPK FTVETLEHTV
NNDSEIWGLL QPYQHLICGK NASGVLSLPE SLNLHRDPQR PSKPGELPMF SQSELRTIEQ
SLLATRVGSI AELSDLVSRA MHHLQPLNAK HHGNGTPMHH KQGALYWEPE ALYTLCYFMH
CPQMEWENPN VEPSKVNLQV ERPFLVLPPL MEWIRVAVAH AGHRRSFSMD SDDVRQAARL
LLPGVDCEPR QLKADDCFCA SRKLDAVAIE AKFKQDLGFR MLNCGRTDLV KQAVSLLGPD
GINTMSEQGM TPLMYACVRG DEAMVQMLLD AGADLNVEVV STPHKYPSVH PETRHWTALT
FAVLHGHIPV VQLLLDAGAK VEGSVEHGEE NYSETPLQLA AAVGNFELVS LLLERGADPL
IGTMYRNGIS TTPQGDMNSF SQAAAHGHRN VFRKLLAQPE KEKSDILSLE EILAEGTDLA
ETAPPPLCAS RNSKAKLRAL REAMYHSAEH GYVDVTIDIR SIGVPWTLHT WLESLRIAFQ
QHRRPLIQCL LKEFKTIQEE EYTEELVTQG LPLMFEILKA SKNEVISQQL CVIFTHCYGP
YPIPKLTEIK RKQTSRLDPH FLNNKEMSDV TFLVEGRPFY AHKVLLFTAS PRFKALLSSK
PTNDNTCIEI GYVKYPIFQL VMQYLYYGGP ESLLIKNNEI MELLSAAKFF QLEALQRHCE
IICAKSINTD NCVDIYSHAK FLGVTELSAY CEGYFLKNMM VLIENEAFKQ LLYDKNGEGA
GQDVLQDLQR TLAIRIQSIH LSSSKGSVV
