ID   TMM98_BOVIN             Reviewed;         226 AA.
AC   Q2HJB9;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Transmembrane protein 98;
GN   Name=TMEM98;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a negative regulator of MYRF in oligodendrocyte
CC       differentiation and myelination. Interacts with the C-terminal of MYRF
CC       inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The
CC       secreted form promotes differentiation of T helper 1 cells (Th1).
CC       {ECO:0000250|UniProtKB:Q91X86}.
CC   -!- SUBUNIT: Interacts (via N-terminal region) with MYRF; the interaction
CC       inhibits MYRF self-cleavage. {ECO:0000250|UniProtKB:Q91X86}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q91X86}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y2Y6}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q9Y2Y6}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y2Y6}. Secreted
CC       {ECO:0000250|UniProtKB:Q91X86}. Secreted, extracellular exosome
CC       {ECO:0000250|UniProtKB:Q9Y2Y6}. Note=Secreted by exosomes through a
CC       non-classical pathway. {ECO:0000250|UniProtKB:Q9Y2Y6}.
CC   -!- SIMILARITY: Belongs to the TMEM98 family. {ECO:0000305}.
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DR   EMBL; BC113208; AAI13209.1; -; mRNA.
DR   RefSeq; NP_001039611.1; NM_001046146.1.
DR   AlphaFoldDB; Q2HJB9; -.
DR   SMR; Q2HJB9; -.
DR   STRING; 9913.ENSBTAP00000011732; -.
DR   PaxDb; Q2HJB9; -.
DR   GeneID; 513445; -.
DR   KEGG; bta:513445; -.
DR   CTD; 26022; -.
DR   eggNOG; ENOG502QT8U; Eukaryota.
DR   InParanoid; Q2HJB9; -.
DR   OrthoDB; 1413051at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0070062; C:extracellular exosome; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0031642; P:negative regulation of myelination; ISS:UniProtKB.
DR   GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:UniProtKB.
DR   GO; GO:1900181; P:negative regulation of protein localization to nucleus; ISS:UniProtKB.
DR   GO; GO:0010955; P:negative regulation of protein processing; ISS:UniProtKB.
DR   GO; GO:0045063; P:T-helper 1 cell differentiation; ISS:UniProtKB.
DR   InterPro; IPR029668; TMEM98.
DR   PANTHER; PTHR32510; PTHR32510; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Secreted; Transmembrane; Transmembrane helix.
FT   CHAIN           1..226
FT                   /note="Transmembrane protein 98"
FT                   /id="PRO_0000251710"
FT   TOPO_DOM        1..3
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2Y6"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        25..226
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2Y6"
FT   REGION          1..88
FT                   /note="Required for interaction with MYRF"
FT                   /evidence="ECO:0000250|UniProtKB:Q91X86"
FT   REGION          207..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  24572 MW;  A3A6B7B73F9E89C8 CRC64;
     METVVIVAIG VLATIFLASF AALVVVCRQR YCRPRDLLQC YDSKPIVDLI GAMETQSEPS
     ELELDDVVIT NPHIEAILEN EDWIEDASGL MSHCIAILKI CHTLTEKLVA MTMGSGAKMK
     TSASLSDIIV VAKRISPRVD DVVKSMYPPL DPKLLDARTT ALLLSVSHLV LVTRNACHLT
     GGLDWIDQSL TAAEEHLEVL REAALASEPD KGLPGPEGFL QEQSAI