ID   TMM98_RAT               Reviewed;         226 AA.
AC   Q6AYS5;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Transmembrane protein 98;
GN   Name=Tmem98;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Functions as a negative regulator of MYRF in oligodendrocyte
CC       differentiation and myelination. Interacts with the C-terminal of MYRF
CC       inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The
CC       secreted form promotes differentiation of T helper 1 cells (Th1).
CC       {ECO:0000250|UniProtKB:Q91X86}.
CC   -!- SUBUNIT: Interacts (via N-terminal region) with MYRF; the interaction
CC       inhibits MYRF self-cleavage. {ECO:0000250|UniProtKB:Q91X86}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q91X86}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y2Y6}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q9Y2Y6}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y2Y6}. Secreted
CC       {ECO:0000250|UniProtKB:Q91X86}. Secreted, extracellular exosome
CC       {ECO:0000250|UniProtKB:Q9Y2Y6}. Note=Secreted by exosomes through a
CC       non-classical pathway. {ECO:0000250|UniProtKB:Q9Y2Y6}.
CC   -!- SIMILARITY: Belongs to the TMEM98 family. {ECO:0000305}.
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DR   EMBL; BC078932; AAH78932.1; -; mRNA.
DR   RefSeq; NP_001007673.1; NM_001007672.1.
DR   AlphaFoldDB; Q6AYS5; -.
DR   SMR; Q6AYS5; -.
DR   STRING; 10116.ENSRNOP00000038394; -.
DR   PaxDb; Q6AYS5; -.
DR   PRIDE; Q6AYS5; -.
DR   Ensembl; ENSRNOT00000037072; ENSRNOP00000038394; ENSRNOG00000021316.
DR   GeneID; 303356; -.
DR   KEGG; rno:303356; -.
DR   CTD; 26022; -.
DR   RGD; 1359736; Tmem98.
DR   eggNOG; ENOG502QT8U; Eukaryota.
DR   GeneTree; ENSGT00390000012062; -.
DR   HOGENOM; CLU_084317_0_0_1; -.
DR   InParanoid; Q6AYS5; -.
DR   OMA; RHRYCRP; -.
DR   OrthoDB; 1413051at2759; -.
DR   PhylomeDB; Q6AYS5; -.
DR   TreeFam; TF336444; -.
DR   PRO; PR:Q6AYS5; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000021316; Expressed in stomach and 20 other tissues.
DR   Genevisible; Q6AYS5; RN.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0070062; C:extracellular exosome; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0031642; P:negative regulation of myelination; ISS:UniProtKB.
DR   GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:UniProtKB.
DR   GO; GO:1900181; P:negative regulation of protein localization to nucleus; ISS:UniProtKB.
DR   GO; GO:0010955; P:negative regulation of protein processing; ISS:UniProtKB.
DR   GO; GO:0045063; P:T-helper 1 cell differentiation; ISS:UniProtKB.
DR   InterPro; IPR029668; TMEM98.
DR   PANTHER; PTHR32510; PTHR32510; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Secreted; Transmembrane; Transmembrane helix.
FT   CHAIN           1..226
FT                   /note="Transmembrane protein 98"
FT                   /id="PRO_0000251713"
FT   TOPO_DOM        1..3
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2Y6"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        25..226
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2Y6"
FT   REGION          1..88
FT                   /note="Required for interaction with MYRF"
FT                   /evidence="ECO:0000250|UniProtKB:Q91X86"
FT   REGION          207..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  24684 MW;  5F4FC338DA6598D9 CRC64;
     METVVIVAIG VLATIFLASF AALVVVCRQR YCRPRDLLQR YDSKPIVDLI GAMETQSEPS
     ELELDDVVIT NPHIEAILEN EDWIEDASGL MSHCIAILKI CHTLTEKLVA MTMGSGAKMK
     TSASVSDIIV VAKRISPRVD DVVKSMYPPL DPKLLDARTT ALLLSVSHLV LVTRNACHLT
     GGLDWIDQSL SAAEEHLEVL REAALASEPD KSLPNPEGFL QEQSAI