ID   TMM98_XENLA             Reviewed;         226 AA.
AC   Q6INX1;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Transmembrane protein 98;
GN   Name=tmem98;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q91X86}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y2Y6}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q9Y2Y6}; Single-pass type II membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y2Y6}. Secreted
CC       {ECO:0000250|UniProtKB:Q91X86}. Secreted, extracellular exosome
CC       {ECO:0000250|UniProtKB:Q9Y2Y6}. Note=Secreted by exosomes through a
CC       non-classical pathway. {ECO:0000250|UniProtKB:Q9Y2Y6}.
CC   -!- SIMILARITY: Belongs to the TMEM98 family. {ECO:0000305}.
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DR   EMBL; BC072151; AAH72151.1; -; mRNA.
DR   RefSeq; NP_001085130.1; NM_001091661.1.
DR   AlphaFoldDB; Q6INX1; -.
DR   SMR; Q6INX1; -.
DR   DNASU; 432207; -.
DR   GeneID; 432207; -.
DR   KEGG; xla:432207; -.
DR   CTD; 432207; -.
DR   Xenbase; XB-GENE-6255754; tmem98.L.
DR   OMA; RHRYCRP; -.
DR   OrthoDB; 1413051at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 432207; Expressed in liver and 16 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031642; P:negative regulation of myelination; ISS:UniProtKB.
DR   GO; GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:UniProtKB.
DR   GO; GO:1900181; P:negative regulation of protein localization to nucleus; ISS:UniProtKB.
DR   GO; GO:0010955; P:negative regulation of protein processing; ISS:UniProtKB.
DR   InterPro; IPR029668; TMEM98.
DR   PANTHER; PTHR32510; PTHR32510; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Secreted; Transmembrane; Transmembrane helix.
FT   CHAIN           1..226
FT                   /note="Transmembrane protein 98"
FT                   /id="PRO_0000251714"
FT   TOPO_DOM        1..3
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2Y6"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        25..226
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2Y6"
SQ   SEQUENCE   226 AA;  24592 MW;  4DD2E31E4C6C843F CRC64;
     METVVIVAIG VLATIFLASF AALVVVCRQR YCRTKNLLTN YNNKPTVDLI GAMETQSEPS
     DLELDDVVIT NPHIEAILED EDWIEDASGL VSHCIAILKI CHTLTEKLVA MTMGSGAKMK
     SPSSLSDIII VAKRISPRVD DVVRSMYPPL DPKLLDARTT ALLLSVSHLV LVTKNACHLT
     GGMDWIDQSL SAAEDHLAVL REAALATEPE RPMTGADNFL QEQSAI