TMM99_HUMAN
ID TMM99_HUMAN Reviewed; 258 AA.
AC Q8N816; B4DQ34; Q96BP9;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Uncharacterized protein KRT10-AS1 {ECO:0000312|HGNC:HGNC:28305};
DE AltName: Full=Transmembrane protein 99;
DE Flags: Precursor;
GN Name=KRT10-AS1 {ECO:0000312|HGNC:HGNC:28305}; Synonyms=TMEM99;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ARG-95.
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N816-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N816-2; Sequence=VSP_035635;
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DR EMBL; AK097454; BAC05059.1; -; mRNA.
DR EMBL; AK298616; BAG60796.1; -; mRNA.
DR EMBL; CH471152; EAW60682.1; -; Genomic_DNA.
DR EMBL; BC015365; AAH15365.1; -; mRNA.
DR RefSeq; NP_001182315.1; NM_001195386.1.
DR RefSeq; NP_001182316.1; NM_001195387.1.
DR RefSeq; NP_660317.2; NM_145274.3.
DR RefSeq; XP_005257146.1; XM_005257089.4.
DR RefSeq; XP_016879742.1; XM_017024253.1.
DR AlphaFoldDB; Q8N816; -.
DR IntAct; Q8N816; 2.
DR STRING; 9606.ENSP00000482364; -.
DR BioMuta; TMEM99; -.
DR DMDM; 212276470; -.
DR MassIVE; Q8N816; -.
DR PaxDb; Q8N816; -.
DR PRIDE; Q8N816; -.
DR TopDownProteomics; Q8N816-2; -. [Q8N816-2]
DR UCSC; uc002hvj.2; human. [Q8N816-1]
DR GeneCards; KRT10-AS1; -.
DR HGNC; HGNC:28305; KRT10-AS1.
DR MalaCards; KRT10-AS1; -.
DR neXtProt; NX_Q8N816; -.
DR eggNOG; ENOG502R1CC; Eukaryota.
DR HOGENOM; CLU_097763_0_0_1; -.
DR InParanoid; Q8N816; -.
DR PhylomeDB; Q8N816; -.
DR PathwayCommons; Q8N816; -.
DR SignaLink; Q8N816; -.
DR BioGRID-ORCS; 147184; 13 hits in 1087 CRISPR screens.
DR GenomeRNAi; 147184; -.
DR Pharos; Q8N816; Tdark.
DR PRO; PR:Q8N816; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8N816; protein.
DR Genevisible; Q8N816; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..258
FT /note="Uncharacterized protein KRT10-AS1"
FT /id="PRO_0000254551"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 190..258
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_035635"
FT VARIANT 4
FT /note="I -> M (in dbSNP:rs17474506)"
FT /id="VAR_028835"
FT VARIANT 79
FT /note="Y -> H (in dbSNP:rs10558)"
FT /id="VAR_028836"
FT VARIANT 95
FT /note="L -> R (in dbSNP:rs1044806)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_028837"
SQ SEQUENCE 258 AA; 27975 MW; 857594EF02E0FA38 CRC64;
MVGILPLCCS GCVPSLCCSS YVPSVAPTAA HSVRVPHSAG HCGQRVLACS LPQVFLKPWI
FVEHFSSWLS LELFSFLRYL GTLLCACGHR LREGLLLPCL LGVGSWLLFN NWTGGSWFSL
HLQQVSLSQG SHVAAFLPEA IGPGVPVPVS GESTSAQQSH AGWQLSAEAD ACPSVLYSEV
LEWNKNINTY TSFHDFCLIL GIFLFCFVLA VIGLPYIKPG LSLSVALLWQ SLILLSSLVQ
QDSQVHTWGC LFSTFTST
