TMM9B_MOUSE
ID TMM9B_MOUSE Reviewed; 199 AA.
AC Q9JJR8;
DT 10-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Transmembrane protein 9B;
DE Flags: Precursor;
GN Name=Tmem9b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11528127; DOI=10.1159/000056999;
RA Amid C., Bahr A., Mujica A., Sampson N., Bikar S.E., Winterpacht A.,
RA Zabel B., Hankeln T., Schmidt E.R.;
RT "Comparative genomic sequencing reveals a strikingly similar architecture
RT of a conserved syntenic region on human chromosome 11p15.3 (including gene
RT ST5) and mouse chromosome 7.";
RL Cytogenet. Cell Genet. 93:284-290(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Ovary, Pancreas, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Enhances production of pro-inflammatory cytokines induced by
CC TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the
CC NF-kappaB and MAPK pathways. {ECO:0000250|UniProtKB:Q9NQ34}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9NQ34};
CC Single-pass membrane protein {ECO:0000255}. Early endosome membrane
CC {ECO:0000250|UniProtKB:Q9NQ34}; Single-pass membrane protein
CC {ECO:0000255}.
CC -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9NQ34}.
CC -!- SIMILARITY: Belongs to the TMEM9 family. {ECO:0000305}.
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DR EMBL; AJ400878; CAB92295.1; -; Genomic_DNA.
DR EMBL; AK009147; BAB26105.1; -; mRNA.
DR EMBL; AK007430; BAB25033.1; -; mRNA.
DR EMBL; AK077253; BAC36710.1; -; mRNA.
DR EMBL; BC002208; AAH02208.1; -; mRNA.
DR CCDS; CCDS21738.1; -.
DR RefSeq; NP_064434.1; NM_020050.1.
DR AlphaFoldDB; Q9JJR8; -.
DR STRING; 10090.ENSMUSP00000033333; -.
DR GlyGen; Q9JJR8; 1 site.
DR iPTMnet; Q9JJR8; -.
DR PhosphoSitePlus; Q9JJR8; -.
DR EPD; Q9JJR8; -.
DR MaxQB; Q9JJR8; -.
DR PaxDb; Q9JJR8; -.
DR PeptideAtlas; Q9JJR8; -.
DR PRIDE; Q9JJR8; -.
DR ProteomicsDB; 259138; -.
DR Antibodypedia; 48632; 20 antibodies from 11 providers.
DR DNASU; 56786; -.
DR Ensembl; ENSMUST00000033333; ENSMUSP00000033333; ENSMUSG00000031021.
DR GeneID; 56786; -.
DR KEGG; mmu:56786; -.
DR UCSC; uc009jec.1; mouse.
DR CTD; 56674; -.
DR MGI; MGI:1915254; Tmem9b.
DR VEuPathDB; HostDB:ENSMUSG00000031021; -.
DR eggNOG; KOG4007; Eukaryota.
DR GeneTree; ENSGT00390000000819; -.
DR HOGENOM; CLU_093267_2_0_1; -.
DR InParanoid; Q9JJR8; -.
DR OMA; CKYESRN; -.
DR OrthoDB; 1380345at2759; -.
DR PhylomeDB; Q9JJR8; -.
DR TreeFam; TF315146; -.
DR BioGRID-ORCS; 56786; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Tmem9b; mouse.
DR PRO; PR:Q9JJR8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9JJR8; protein.
DR Bgee; ENSMUSG00000031021; Expressed in placenta labyrinth and 260 other tissues.
DR ExpressionAtlas; Q9JJR8; baseline and differential.
DR Genevisible; Q9JJR8; MM.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008853; TMEM9/TMEM9B.
DR PANTHER; PTHR13064; PTHR13064; 1.
DR Pfam; PF05434; Tmemb_9; 1.
PE 1: Evidence at protein level;
KW Endosome; Glycoprotein; Lysosome; Membrane; Phosphoprotein;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..199
FT /note="Transmembrane protein 9B"
FT /id="PRO_0000045787"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 143
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319"
FT MOD_RES 190
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NQ34"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 199 AA; 22607 MW; 476B6FD1BCECA4E5 CRC64;
MASLWCGNLL RLGSGLSMSC LALSVLLLAQ LTGAAKNFED VRCKCICPPY KENPGHIYNK
NISQKDCDCL HVVEPMPVRG PDVEAYCLRC ECKYEERSSV TIKVTIIIYL SILGLLLLYM
VYLTLVEPIL KRRLFGHSQL LQSDDDVGDH QPFANAHDVL ARSRSRANVL NKVEYAQQRW
KLQVQEQRKS VFDRHVVLS
