TMN11_ARATH
ID TMN11_ARATH Reviewed; 658 AA.
AC Q9FYQ8; Q8L424;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Transmembrane 9 superfamily member 11 {ECO:0000305};
DE AltName: Full=Endomembrane protein 6 {ECO:0000303|PubMed:22570441};
DE AltName: Full=Transmembrane nine protein 11 {ECO:0000303|PubMed:20681974};
DE Short=AtTMN11 {ECO:0000303|PubMed:20681974};
DE Flags: Precursor;
GN Name=TMN11 {ECO:0000303|PubMed:20681974};
GN Synonyms=EMP6 {ECO:0000303|PubMed:22570441};
GN OrderedLocusNames=At5g35160 {ECO:0000312|Araport:AT5G35160};
GN ORFNames=T13C12.17 {ECO:0000312|EMBL:BAB10022.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 228-658.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=20681974; DOI=10.1111/j.1399-3054.2010.01404.x;
RA Hegelund J.N., Jahn T.P., Baekgaard L., Palmgren M.G., Schjoerring J.K.;
RT "Transmembrane nine proteins in yeast and Arabidopsis affect cellular metal
RT contents without changing vacuolar morphology.";
RL Physiol. Plantarum 140:355-367(2010).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=22570441; DOI=10.1105/tpc.112.096057;
RA Gao C., Yu C.K., Qu S., San M.W., Li K.Y., Lo S.W., Jiang L.;
RT "The Golgi-localized Arabidopsis endomembrane protein12 contains both
RT endoplasmic reticulum export and Golgi retention signals at its C
RT terminus.";
RL Plant Cell 24:2086-2104(2012).
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:P32802};
CC Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q940G0}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9FYQ8-1; Sequence=Displayed;
CC -!- DOMAIN: The C-terminal KXD/E motif functions as a Golgi retention
CC signal, certainly through the binding to the COP1 coatomer.
CC {ECO:0000250|UniProtKB:Q940G0}.
CC -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM20600.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AP000421; BAB10022.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93935.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM71210.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM71211.1; -; Genomic_DNA.
DR EMBL; AY099749; AAM20600.1; ALT_INIT; mRNA.
DR EMBL; AY128866; AAM91266.1; -; mRNA.
DR RefSeq; NP_001190420.1; NM_001203491.2. [Q9FYQ8-1]
DR RefSeq; NP_001332754.1; NM_001344097.1. [Q9FYQ8-1]
DR RefSeq; NP_001332755.1; NM_001344096.1. [Q9FYQ8-1]
DR AlphaFoldDB; Q9FYQ8; -.
DR SMR; Q9FYQ8; -.
DR STRING; 3702.AT5G35160.2; -.
DR PaxDb; Q9FYQ8; -.
DR PRIDE; Q9FYQ8; -.
DR ProteomicsDB; 234438; -. [Q9FYQ8-1]
DR EnsemblPlants; AT5G35160.2; AT5G35160.2; AT5G35160. [Q9FYQ8-1]
DR EnsemblPlants; AT5G35160.3; AT5G35160.3; AT5G35160. [Q9FYQ8-1]
DR EnsemblPlants; AT5G35160.4; AT5G35160.4; AT5G35160. [Q9FYQ8-1]
DR GeneID; 833470; -.
DR Gramene; AT5G35160.2; AT5G35160.2; AT5G35160. [Q9FYQ8-1]
DR Gramene; AT5G35160.3; AT5G35160.3; AT5G35160. [Q9FYQ8-1]
DR Gramene; AT5G35160.4; AT5G35160.4; AT5G35160. [Q9FYQ8-1]
DR KEGG; ath:AT5G35160; -.
DR Araport; AT5G35160; -.
DR TAIR; locus:2182397; AT5G35160.
DR eggNOG; KOG1278; Eukaryota.
DR HOGENOM; CLU_010714_4_1_1; -.
DR InParanoid; Q9FYQ8; -.
DR PhylomeDB; Q9FYQ8; -.
DR PRO; PR:Q9FYQ8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FYQ8; baseline and differential.
DR Genevisible; Q9FYQ8; AT.
DR GO; GO:0005768; C:endosome; HDA:TAIR.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR GO; GO:0005797; C:Golgi medial cisterna; HDA:TAIR.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0009536; C:plastid; HDA:TAIR.
DR GO; GO:0005802; C:trans-Golgi network; HDA:TAIR.
DR GO; GO:0072657; P:protein localization to membrane; IBA:GO_Central.
DR InterPro; IPR004240; EMP70.
DR PANTHER; PTHR10766; PTHR10766; 1.
DR Pfam; PF02990; EMP70; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endosome; Golgi apparatus; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..658
FT /note="Transmembrane 9 superfamily member 11"
FT /evidence="ECO:0000255"
FT /id="PRO_0000431268"
FT TOPO_DOM 24..291
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 292..312
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..364
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 365..385
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 386..391
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 392..412
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 413..432
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 433..453
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 454..462
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 463..483
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 484..515
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 516..536
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 537..547
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 548..568
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 569..586
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 587..607
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 608..619
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 620..640
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 641..658
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT MOTIF 647..652
FT /note="Endoplasmic reticulum export signal"
FT /evidence="ECO:0000250|UniProtKB:Q940G0"
FT MOTIF 656..658
FT /note="Golgi retention signal"
FT /evidence="ECO:0000250|UniProtKB:Q940G0"
SQ SEQUENCE 658 AA; 74579 MW; 6877C0842BC68AFF CRC64;
MRSMDRFGIW VLAILLVIQS SFGFYLPGSY PHKYEVGDYL NVKVNSLTSI ETEMPFSYYS
LPFCKPSEGI KDSAENLGEL LMGDRIENSP YRFRMFKNES EIFLCQTDKL SADSLKLLKK
RIDEMYQVNP MLDNLPAIRY TKRDGYVLRW TGYPVGIKVQ DVYYVFNHLK FKVLVHKYEE
AANVARVMGT GDAAEVIPTI GKKDSDVPGY MVVGFEVVPC SFAHNGESTK KLKMYERYTT
PIKCDSTRVS MSVKEGQSIV FSYEVSFEES DIKWPSRWDA YLKMEGSKVH WFSILNSLMV
ITFLAGIVLV IFLRTVRRDL TRYEELDKEA QAQMNEELSG WKLVVGDVFR APSNASLLCV
MVGDGVQILG MAVVTILFAA LGFMSPASRG TLITGMLFFY MILGIAAGYV SVRLWRTIGC
GEHRGWMSVA WKAACFFPGI AFLILTTLNF LLWGSHSTGA IPFSLFVILL LLWFCISVPL
TLIGGYFGAK APHIEFPVRT NQIPREIPAQ KYPSWLLVLG AGTLPFGTLF IELFFIMSSI
WMGRVYYVFG FLFVVLILLV VVCAEVSLVL TYMHLCVEDY KWWWKSFFAS GSVAIYIFIY
SINYLVFDLK SLSGPVSATL YLGYSLFMVL AIMLATGTVG FLSSFWFVHY LFSSVKLD
