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TMN3_YEAST
ID   TMN3_YEAST              Reviewed;         706 AA.
AC   P40071; D3DM19;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Transmembrane 9 superfamily member 3;
DE   Flags: Precursor;
GN   Name=TMN3; OrderedLocusNames=YER113C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA   Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA   Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [4]
RP   TOPOLOGY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 208353 / W303-1A;
RX   PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA   Kim H., Melen K., Oesterberg M., von Heijne G.;
RT   "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
RN   [5]
RP   FUNCTION.
RX   PubMed=18178563; DOI=10.1074/jbc.m704484200;
RA   Froquet R., Cherix N., Birke R., Benghezal M., Cameroni E., Letourneur F.,
RA   Moesch H.-U., De Virgilio C., Cosson P.;
RT   "Control of cellular physiology by TM9 proteins in yeast and
RT   Dictyostelium.";
RL   J. Biol. Chem. 283:6764-6772(2008).
RN   [6]
RP   FUNCTION.
RX   PubMed=20681974; DOI=10.1111/j.1399-3054.2010.01404.x;
RA   Hegelund J.N., Jahn T.P., Baekgaard L., Palmgren M.G., Schjoerring J.K.;
RT   "Transmembrane nine proteins in yeast and Arabidopsis affect cellular metal
RT   contents without changing vacuolar morphology.";
RL   Physiol. Plantarum 140:355-367(2010).
CC   -!- FUNCTION: With EMP70 and TMN2, plays a critical role in the late stages
CC       of a nutrient-controlled pathway notably regulating FLO11 gene
CC       expression. Acts downstream of RAS2 and TOR. Essential for cell
CC       adhesion and filamentous growth. May play a role as effector of
CC       cellular copper homeostasis. {ECO:0000269|PubMed:18178563,
CC       ECO:0000269|PubMed:20681974}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000269|PubMed:14562095}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:14562095}.
CC   -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
CC       {ECO:0000305}.
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DR   EMBL; U18916; AAC03211.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07773.1; -; Genomic_DNA.
DR   PIR; S50616; S50616.
DR   RefSeq; NP_011038.3; NM_001179003.3.
DR   AlphaFoldDB; P40071; -.
DR   BioGRID; 36858; 69.
DR   DIP; DIP-849N; -.
DR   IntAct; P40071; 7.
DR   MINT; P40071; -.
DR   STRING; 4932.YER113C; -.
DR   iPTMnet; P40071; -.
DR   MaxQB; P40071; -.
DR   PaxDb; P40071; -.
DR   PRIDE; P40071; -.
DR   EnsemblFungi; YER113C_mRNA; YER113C; YER113C.
DR   GeneID; 856849; -.
DR   KEGG; sce:YER113C; -.
DR   SGD; S000000915; TMN3.
DR   VEuPathDB; FungiDB:YER113C; -.
DR   eggNOG; KOG1278; Eukaryota.
DR   HOGENOM; CLU_010714_4_0_1; -.
DR   InParanoid; P40071; -.
DR   OMA; CPGASKD; -.
DR   BioCyc; YEAST:G3O-30277-MON; -.
DR   PRO; PR:P40071; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   RNAct; P40071; protein.
DR   GO; GO:0005794; C:Golgi apparatus; HDA:SGD.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006878; P:cellular copper ion homeostasis; IMP:UniProtKB.
DR   GO; GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0072657; P:protein localization to membrane; IBA:GO_Central.
DR   GO; GO:0007124; P:pseudohyphal growth; IGI:SGD.
DR   GO; GO:0007034; P:vacuolar transport; IGI:SGD.
DR   InterPro; IPR004240; EMP70.
DR   PANTHER; PTHR10766; PTHR10766; 1.
DR   Pfam; PF02990; EMP70; 1.
PE   1: Evidence at protein level;
KW   Golgi apparatus; Ion transport; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..706
FT                   /note="Transmembrane 9 superfamily member 3"
FT                   /id="PRO_0000034373"
FT   TOPO_DOM        34..290
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        312..371
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        393..405
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        427..456
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        478..494
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        495..515
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        516..553
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        554..574
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        575..592
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        593..613
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        614..637
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        638..658
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        659..665
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        666..686
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        687..706
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   706 AA;  81546 MW;  8FD8A66E45B1BFC2 CRC64;
     MRVRPKRSVI TLMAIVVVML ILRNQFYSSR TRGHGQEPVI SSSQKNLYDG WITPNFYRKG
     DPLELIVNKV ESDLTQLPYA YYDLPFTCPP TMHKKPLHLS LNEIIRGDRK WESDYKLKFG
     EDNPCETLCA RKTTKEGMQT LDKLVREGYV VQWLIDDELP AATTFISTTD HKKYYASGFP
     LGFIDPDTDK TYLHNHVMLV IRFHASDNDK NTIVGFEVYP RSVSDYHCPG ASKNYEQYEI
     VIPEDENELT YLPFTYSVYW REEFEVDWNH RWDYFLNAGE LSDEQSIQFH WMSLANSVGI
     VLSISFITLI IYVRVMYTDK SNSKSPKYMI NIEGIETEDD LDDDKYGKYS VYTVAKDWIQ
     NGRPNLFGLK VLILLVSFGV QFLFTIIGSL TISCSMNKLH NVRNSVLTMA ILFFVLGAFM
     ASFVGTRLSM VTKTKRTKAN YLDDNRYLKD YKKFSPIFTI LCGSSLPGIV MVSTFLLNSI
     VWAHDSTSAL PFKTIVFFMS IYFIVCIPLS LFGGIVANNI PLPQYWLSGI TKDESNSDGN
     GLFVPKSRAK FNPLVYCGIY LCGIFPLLVI YVEMQYVYKS LWLEKTTFYY FYGFLFLSII
     LLCVLTMEIS IIGSYLLMRF CFEDKVVRNN WRWKCFEMGF SGGVYMELYS LYYIFAVLNI
     HGFSSILISI CYSLIFNVMC SLGLGALSYL TASWFINKIY HQKVNL
 
 
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