BTBDG_HUMAN
ID BTBDG_HUMAN Reviewed; 506 AA.
AC Q32M84; A6NM63; Q4VXL1; Q96LN0;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=BTB/POZ domain-containing protein 16;
GN Name=BTBD16; Synonyms=C10orf87;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q32M84-2; Q9HAT0: ROPN1; NbExp=3; IntAct=EBI-11961432, EBI-1378139;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q32M84-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q32M84-2; Sequence=VSP_019929;
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DR EMBL; AK058088; BAB71658.1; -; mRNA.
DR EMBL; AL135793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX842243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC109262; AAI09263.1; -; mRNA.
DR EMBL; BC109261; AAI09262.1; -; mRNA.
DR CCDS; CCDS31301.1; -. [Q32M84-1]
DR RefSeq; NP_001305118.1; NM_001318189.1. [Q32M84-2]
DR RefSeq; NP_653188.2; NM_144587.3. [Q32M84-1]
DR RefSeq; XP_016871125.1; XM_017015636.1. [Q32M84-2]
DR AlphaFoldDB; Q32M84; -.
DR BioGRID; 125616; 2.
DR IntAct; Q32M84; 1.
DR STRING; 9606.ENSP00000260723; -.
DR iPTMnet; Q32M84; -.
DR PhosphoSitePlus; Q32M84; -.
DR BioMuta; BTBD16; -.
DR DMDM; 110832778; -.
DR EPD; Q32M84; -.
DR MassIVE; Q32M84; -.
DR MaxQB; Q32M84; -.
DR PaxDb; Q32M84; -.
DR PeptideAtlas; Q32M84; -.
DR PRIDE; Q32M84; -.
DR ProteomicsDB; 61594; -. [Q32M84-1]
DR ProteomicsDB; 61595; -. [Q32M84-2]
DR Antibodypedia; 53241; 83 antibodies from 18 providers.
DR DNASU; 118663; -.
DR Ensembl; ENST00000260723.6; ENSP00000260723.4; ENSG00000138152.10. [Q32M84-1]
DR GeneID; 118663; -.
DR KEGG; hsa:118663; -.
DR MANE-Select; ENST00000260723.6; ENSP00000260723.4; NM_144587.5; NP_653188.2.
DR UCSC; uc001lgc.2; human. [Q32M84-1]
DR CTD; 118663; -.
DR GeneCards; BTBD16; -.
DR HGNC; HGNC:26340; BTBD16.
DR HPA; ENSG00000138152; Tissue enhanced (skin, testis, urinary bladder).
DR neXtProt; NX_Q32M84; -.
DR OpenTargets; ENSG00000138152; -.
DR PharmGKB; PA134900594; -.
DR VEuPathDB; HostDB:ENSG00000138152; -.
DR eggNOG; KOG4682; Eukaryota.
DR GeneTree; ENSGT00940000161718; -.
DR HOGENOM; CLU_025904_0_0_1; -.
DR InParanoid; Q32M84; -.
DR OMA; ALSQMCK; -.
DR OrthoDB; 638500at2759; -.
DR PhylomeDB; Q32M84; -.
DR TreeFam; TF316048; -.
DR PathwayCommons; Q32M84; -.
DR SignaLink; Q32M84; -.
DR BioGRID-ORCS; 118663; 8 hits in 1096 CRISPR screens.
DR ChiTaRS; BTBD16; human.
DR GenomeRNAi; 118663; -.
DR Pharos; Q32M84; Tbio.
DR PRO; PR:Q32M84; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q32M84; protein.
DR Bgee; ENSG00000138152; Expressed in C1 segment of cervical spinal cord and 83 other tissues.
DR Genevisible; Q32M84; HS.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR042833; BTBD16.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR46843; PTHR46843; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..506
FT /note="BTB/POZ domain-containing protein 16"
FT /id="PRO_0000247121"
FT DOMAIN 150..206
FT /note="BTB"
FT VAR_SEQ 6
FT /note="T -> TQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019929"
FT VARIANT 318
FT /note="R -> Q (in dbSNP:rs2421013)"
FT /id="VAR_027070"
FT VARIANT 331
FT /note="G -> D (in dbSNP:rs986178)"
FT /id="VAR_027071"
FT VARIANT 439
FT /note="H -> P (in dbSNP:rs1048347)"
FT /id="VAR_027072"
FT VARIANT 472
FT /note="Q -> R (in dbSNP:rs10510108)"
FT /id="VAR_027073"
FT CONFLICT 97
FT /note="Q -> R (in Ref. 1; BAB71658)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 506 AA; 58481 MW; A5E006B7F7014AD4 CRC64;
MIMSNTHKAR LERRVTGSTN RWRLPKQPFS GDLLSLSQMC KALSIDFEEA LRNPDRLCIS
QIQKFFFENF KNKDIQSGEA DVILECLGFK WELHQPQLFQ SETLAKLYLK ALAQGTTHPL
RELEELLRAQ SPKKTKEKSP AKRIIISLKI NDPLVTKVAF ATALKNLYMS EVEINLEDLL
GVLASAHILQ FSGLFQRCVD VMIARLKPST IKKFYEAGCK YKEEQLTTGC EKWLEMNLVP
LGGTQIHLHK IPQDLLHKVL KSPRLFTFSE FHLLKTMLLW VFLQLNYKIQ AIPTYETVMT
FFKSFPENCC FLDRDIGRSL RPLFLCLRLH GITKGKDLEV LRHLNFFPES WLDQVTVNHY
HALENGGDMV HLKDLNTQAV RFGLLFNQEN TTYSKTIALY GFFFKIKGLK HDTTSYSFYM
QRIKHTDLES PSAVYEHNHV SLRAARLVKY EIRAEALVDG KWQEFRTNQI KQKFGLTTSS
CKSHTLKIQT VGIPIYVSFA FIFPAS
