TMN4_ARATH
ID TMN4_ARATH Reviewed; 593 AA.
AC Q9FHT4;
DT 26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Transmembrane 9 superfamily member 4 {ECO:0000305};
DE AltName: Full=Endomembrane protein 10 {ECO:0000303|PubMed:22570441};
DE AltName: Full=Transmembrane nine protein 4 {ECO:0000303|PubMed:20681974};
DE Short=AtTMN4 {ECO:0000303|PubMed:20681974};
DE Flags: Precursor;
GN Name=TMN4 {ECO:0000303|PubMed:20681974};
GN Synonyms=EMP10 {ECO:0000303|PubMed:22570441};
GN OrderedLocusNames=At5g37310 {ECO:0000312|Araport:AT5G37310};
GN ORFNames=MNJ8.10 {ECO:0000312|EMBL:BAB09103.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:BAB09103.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=20681974; DOI=10.1111/j.1399-3054.2010.01404.x;
RA Hegelund J.N., Jahn T.P., Baekgaard L., Palmgren M.G., Schjoerring J.K.;
RT "Transmembrane nine proteins in yeast and Arabidopsis affect cellular metal
RT contents without changing vacuolar morphology.";
RL Physiol. Plantarum 140:355-367(2010).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=22570441; DOI=10.1105/tpc.112.096057;
RA Gao C., Yu C.K., Qu S., San M.W., Li K.Y., Lo S.W., Jiang L.;
RT "The Golgi-localized Arabidopsis endomembrane protein12 contains both
RT endoplasmic reticulum export and Golgi retention signals at its C
RT terminus.";
RL Plant Cell 24:2086-2104(2012).
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:P32802};
CC Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q940G0}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- DOMAIN: The C-terminal KXD/E motif functions as a Golgi retention
CC signal, certainly through the binding to the COP1 coatomer.
CC {ECO:0000250|UniProtKB:Q940G0}.
CC -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
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DR EMBL; AB017069; BAB09103.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94164.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68722.1; -; Genomic_DNA.
DR EMBL; AK226936; BAE99006.1; -; mRNA.
DR RefSeq; NP_001330448.1; NM_001344181.1.
DR RefSeq; NP_198547.3; NM_123090.4.
DR AlphaFoldDB; Q9FHT4; -.
DR STRING; 3702.AT5G37310.1; -.
DR PaxDb; Q9FHT4; -.
DR PRIDE; Q9FHT4; -.
DR ProteomicsDB; 234452; -.
DR EnsemblPlants; AT5G37310.1; AT5G37310.1; AT5G37310.
DR EnsemblPlants; AT5G37310.2; AT5G37310.2; AT5G37310.
DR GeneID; 833705; -.
DR Gramene; AT5G37310.1; AT5G37310.1; AT5G37310.
DR Gramene; AT5G37310.2; AT5G37310.2; AT5G37310.
DR KEGG; ath:AT5G37310; -.
DR Araport; AT5G37310; -.
DR TAIR; locus:2169100; AT5G37310.
DR eggNOG; KOG1277; Eukaryota.
DR HOGENOM; CLU_010714_0_2_1; -.
DR InParanoid; Q9FHT4; -.
DR OMA; AICIELY; -.
DR OrthoDB; 641127at2759; -.
DR PhylomeDB; Q9FHT4; -.
DR PRO; PR:Q9FHT4; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FHT4; baseline and differential.
DR Genevisible; Q9FHT4; AT.
DR GO; GO:0005768; C:endosome; HDA:TAIR.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; HDA:TAIR.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000138; C:Golgi trans cisterna; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0009505; C:plant-type cell wall; HDA:TAIR.
DR GO; GO:0005802; C:trans-Golgi network; HDA:TAIR.
DR GO; GO:0072657; P:protein localization to membrane; IBA:GO_Central.
DR InterPro; IPR004240; EMP70.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10766; PTHR10766; 1.
DR Pfam; PF02990; EMP70; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Endosome; Golgi apparatus; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..593
FT /note="Transmembrane 9 superfamily member 4"
FT /evidence="ECO:0000255"
FT /id="PRO_0000431261"
FT TOPO_DOM 26..230
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 231..251
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 304..324
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..326
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 327..347
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 348..366
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 367..387
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 388..398
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 399..419
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 420..453
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 454..474
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 475..486
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 487..507
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 508..522
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 523..543
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 544..554
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 555..575
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 576..593
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT MOTIF 582..587
FT /note="Endoplasmic reticulum export signal"
FT /evidence="ECO:0000250|UniProtKB:Q940G0"
FT MOTIF 591..593
FT /note="Golgi retention signal"
FT /evidence="ECO:0000250|UniProtKB:Q940G0"
SQ SEQUENCE 593 AA; 68079 MW; 1180DDBEE2871292 CRC64;
MVLLPSMTSL LLVFLFLYGV SPVISDGSDH RYKVGDDVPL YANKVGPFHN PSETYRYFDL
PFCSSAPVKE KKEALGEVLN GDRLVSAPYK LEFLGEKNSE VACRKRLSRE DVAKFRDVIA
KDYYFQMYYD DLPIWGFLGK VVKEGKTDPS EYKYYLFNHL QFEIFYNKDR VIEIIVRTDQ
NFLVDLTEDK EVQVDFTYTV RWKETEIPFE KRMEKYSLAS SMPHHLEIHW FSIINSCVTV
LLLTGFLATI LMRVLKNDFV KYAHDEEAVD DQEETGWKLI HGDVFRFPKH KSLLAAALGS
GTQLFTLAVF IFMLALVGVF YPYNRGALFT ALVVIYALTS GIAGYTAASF YCQLEGTNWV
RNVILTGSLF CGPLLITFSF LNTVAIAYQA TAALPFGTIV VIFLIWALVT SPLLILGGIA
GKNRKSEFQA PCRTTKYPRE IPPMRWYRRT LPQMAMAGFL PFSAIYIELY YIFASVWGHR
IYTIYSILSI VFLILVIVTA FITVALTYFQ LAAEDHEWWW RSLLCGGSTG LFIYAYCLYY
YYARSDMSGF MQTSFFFGYM ACICYGFFLM LGTIGFCASL LFVRHIYRSI KCE
