位置:首页 > 蛋白库 > TMN5_ARATH
TMN5_ARATH
ID   TMN5_ARATH              Reviewed;         589 AA.
AC   F4HW17; F4HW18; Q94AV9; Q9SCX1; Q9SJF5;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Transmembrane 9 superfamily member 5 {ECO:0000305};
DE   AltName: Full=Endomembrane protein 11 {ECO:0000303|PubMed:22570441};
DE   AltName: Full=Transmembrane nine protein 5 {ECO:0000303|PubMed:20681974};
DE            Short=AtTMN5 {ECO:0000303|PubMed:20681974};
DE   Flags: Precursor;
GN   Name=TMN5 {ECO:0000303|PubMed:20681974};
GN   Synonyms=DIDI 8C-5D {ECO:0000312|EMBL:CAB62549.1},
GN   EMP11 {ECO:0000303|PubMed:22570441};
GN   OrderedLocusNames=At1g08350 {ECO:0000312|Araport:AT1G08350};
GN   ORFNames=T27G7.5 {ECO:0000312|EMBL:AAF22904.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 524-589 (ISOFORM 1/2), TISSUE SPECIFICITY,
RP   AND INDUCTION.
RC   TISSUE=Root;
RX   PubMed=11277426; DOI=10.1094/mpmi.2001.14.3.288;
RA   Vercauteren I., van der Schueren E., Van Montagu M., Gheysen G.;
RT   "Arabidopsis thaliana genes expressed in the early compatible interaction
RT   with root-knot nematodes.";
RL   Mol. Plant Microbe Interact. 14:288-299(2001).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=20681974; DOI=10.1111/j.1399-3054.2010.01404.x;
RA   Hegelund J.N., Jahn T.P., Baekgaard L., Palmgren M.G., Schjoerring J.K.;
RT   "Transmembrane nine proteins in yeast and Arabidopsis affect cellular metal
RT   contents without changing vacuolar morphology.";
RL   Physiol. Plantarum 140:355-367(2010).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=22570441; DOI=10.1105/tpc.112.096057;
RA   Gao C., Yu C.K., Qu S., San M.W., Li K.Y., Lo S.W., Jiang L.;
RT   "The Golgi-localized Arabidopsis endomembrane protein12 contains both
RT   endoplasmic reticulum export and Golgi retention signals at its C
RT   terminus.";
RL   Plant Cell 24:2086-2104(2012).
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:P32802};
CC       Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q940G0}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=F4HW17-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=F4HW17-2; Sequence=VSP_057142;
CC   -!- TISSUE SPECIFICITY: Expressed in the root cap and in giant cells.
CC       {ECO:0000269|PubMed:11277426}.
CC   -!- INDUCTION: Up-regulated upon nematode infection.
CC       {ECO:0000269|PubMed:11277426}.
CC   -!- DOMAIN: The C-terminal KXD/E motif functions as a Golgi retention
CC       signal, certainly through the binding to the COP1 coatomer.
CC       {ECO:0000250|UniProtKB:Q940G0}.
CC   -!- SIMILARITY: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF22904.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC006932; AAF22904.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE28279.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE28280.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM60891.1; -; Genomic_DNA.
DR   EMBL; AY045680; AAK74038.1; -; mRNA.
DR   EMBL; BT001044; AAN46798.1; -; mRNA.
DR   EMBL; AJ249959; CAB62549.1; -; mRNA.
DR   RefSeq; NP_001077489.1; NM_001084020.1. [F4HW17-1]
DR   RefSeq; NP_001323140.1; NM_001331772.1.
DR   RefSeq; NP_001323141.1; NM_001331771.1. [F4HW17-1]
DR   RefSeq; NP_563812.1; NM_100708.2. [F4HW17-2]
DR   AlphaFoldDB; F4HW17; -.
DR   STRING; 3702.AT1G08350.2; -.
DR   PaxDb; F4HW17; -.
DR   PRIDE; F4HW17; -.
DR   EnsemblPlants; AT1G08350.1; AT1G08350.1; AT1G08350. [F4HW17-2]
DR   EnsemblPlants; AT1G08350.2; AT1G08350.2; AT1G08350. [F4HW17-1]
DR   EnsemblPlants; AT1G08350.3; AT1G08350.3; AT1G08350. [F4HW17-1]
DR   GeneID; 837355; -.
DR   Gramene; AT1G08350.1; AT1G08350.1; AT1G08350. [F4HW17-2]
DR   Gramene; AT1G08350.2; AT1G08350.2; AT1G08350. [F4HW17-1]
DR   Gramene; AT1G08350.3; AT1G08350.3; AT1G08350. [F4HW17-1]
DR   KEGG; ath:AT1G08350; -.
DR   Araport; AT1G08350; -.
DR   TAIR; locus:2201806; AT1G08350.
DR   eggNOG; KOG1277; Eukaryota.
DR   HOGENOM; CLU_010714_0_2_1; -.
DR   InParanoid; F4HW17; -.
DR   OMA; LYELKFR; -.
DR   PRO; PR:F4HW17; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; F4HW17; baseline and differential.
DR   Genevisible; F4HW17; AT.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0072657; P:protein localization to membrane; IBA:GO_Central.
DR   GO; GO:0009624; P:response to nematode; IEP:UniProtKB.
DR   InterPro; IPR004240; EMP70.
DR   PANTHER; PTHR10766; PTHR10766; 1.
DR   Pfam; PF02990; EMP70; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Endosome; Golgi apparatus; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..589
FT                   /note="Transmembrane 9 superfamily member 5"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000431262"
FT   TOPO_DOM        25..227
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        228..248
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..291
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        292..312
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        313..321
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        322..342
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        343..361
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        362..382
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        383..394
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        395..415
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        416..450
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        451..471
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        472..482
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        483..503
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        504..518
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        519..539
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        540..550
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        551..571
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        572..589
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   MOTIF           578..583
FT                   /note="Endoplasmic reticulum export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q940G0"
FT   MOTIF           587..589
FT                   /note="Golgi retention signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q940G0"
FT   VAR_SEQ         1..81
FT                   /note="Missing (in isoform 2)"
FT                   /id="VSP_057142"
FT   CONFLICT        582
FT                   /note="I -> V (in Ref. 3; AAK74038/AAN46798)"
SQ   SEQUENCE   589 AA;  67678 MW;  253DEEACFEDD7A0D CRC64;
     MAQFLLTVLQ VLLALTFWIG IGSGSSNHYN AGDHVPLFVN KVGPLHNPSE TYQYYDLPFC
     RRGPVIEKQE TLGEVLNGDR LMSSLYKLKF REDKTHFVLC RKRLTSSDIA RFRDIIAQDY
     YFQMYYDDLP LWGFVGKVEG DYFGQGEKHT KYYIFSHLKF NVLYNADKVI EINSFSDPSY
     MVDISENTEI DVQFTYSVSW NLTSERSETR MNKYSRASFH PISQKIHFFS FLNSITVVVL
     LIGLISFLFM RHLKNELRSY SIGDEEERKE AGWKLVHSDV FRCPRNISWL CAILGTGTQL
     LILIIALFAL AFTGFLYPYN RGMLLTSLVI MYTLTSIVAG YTSTSFHSQF EGNKQKRSVR
     LAGILYPVPF FIILSVLNTV AITYGATAAL PFGTIVIIIL IFTLLNIPFL MLGGVLGNRF
     GLLEFQPPSA VKRNPREIPP QNWYRRKLYQ VFLGGFVPFS AVVLEWHQLY ASLWGFKIYT
     SPGIMLFTFI VLIFLSSSVG IILTYIQLSG EDHEWWWRSI LCGGFTAVFM YGYGVLFYLR
     SDMTGFLQLS FYLGYTALLC YALFLVLGTI SFLASLMFIR HIYRSVKLE
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024