ID   TMOD4_BOVIN             Reviewed;         345 AA.
AC   Q0VC48;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Tropomodulin-4;
DE   AltName: Full=Skeletal muscle tropomodulin;
DE            Short=Sk-Tmod;
GN   Name=TMOD4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Blocks the elongation and depolymerization of the actin
CC       filaments at the pointed end. The Tmod/TM complex contributes to the
CC       formation of the short actin protofilament, which in turn defines the
CC       geometry of the membrane skeleton (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds to the N-terminus of tropomyosin and to actin.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q9NZQ9}. Note=In myofibrils with sarcomeric
CC       structure, localizes to the pointed end of actin thin filaments.
CC       {ECO:0000250|UniProtKB:Q9NZQ9}.
CC   -!- SIMILARITY: Belongs to the tropomodulin family. {ECO:0000305}.
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DR   EMBL; BC120356; AAI20357.1; -; mRNA.
DR   RefSeq; NP_001068683.1; NM_001075215.1.
DR   RefSeq; XP_005203909.1; XM_005203852.3.
DR   AlphaFoldDB; Q0VC48; -.
DR   SMR; Q0VC48; -.
DR   STRING; 9913.ENSBTAP00000043640; -.
DR   PaxDb; Q0VC48; -.
DR   Ensembl; ENSBTAT00000046331; ENSBTAP00000043640; ENSBTAG00000018071.
DR   GeneID; 505645; -.
DR   KEGG; bta:505645; -.
DR   CTD; 29765; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018071; -.
DR   VGNC; VGNC:36137; TMOD4.
DR   eggNOG; KOG3735; Eukaryota.
DR   GeneTree; ENSGT00940000158734; -.
DR   HOGENOM; CLU_031052_0_1_1; -.
DR   InParanoid; Q0VC48; -.
DR   OMA; SIIRFGY; -.
DR   OrthoDB; 1025132at2759; -.
DR   TreeFam; TF315841; -.
DR   Reactome; R-BTA-390522; Striated Muscle Contraction.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000018071; Expressed in longissimus thoracis muscle and 103 other tissues.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0030016; C:myofibril; IBA:GO_Central.
DR   GO; GO:0005865; C:striated muscle thin filament; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0005523; F:tropomyosin binding; IBA:GO_Central.
DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR   GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR   GO; GO:0030239; P:myofibril assembly; IBA:GO_Central.
DR   GO; GO:0051694; P:pointed-end actin filament capping; IEA:InterPro.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR004934; TMOD.
DR   InterPro; IPR030129; TMOD4.
DR   PANTHER; PTHR10901; PTHR10901; 1.
DR   PANTHER; PTHR10901:SF9; PTHR10901:SF9; 1.
DR   Pfam; PF03250; Tropomodulin; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..345
FT                   /note="Tropomodulin-4"
FT                   /id="PRO_0000281915"
FT   REGION          42..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  39184 MW;  9C4BBE388C1B7ED2 CRC64;
     MSSYQKELEK YRDIDEDEIL KTLSPEELEQ LDCELQEMDP ENMLLPAGLR QRDQTKKSPT
     GPLDREALLQ YLEQQALEVK ERDDLVPFTG EKKGKPYIQP KREIPVEEQV TLEPELEEAL
     AHATDAEMCD IAAILGMYTL MSNKQYYDAI CSGEICNTEG ISSVVQPDKY KPVPDEPPNP
     TNIEEILKSV RSNDKEVEEV NLNNIQDIPI PMLTELCEAM KTNTHVRSFS LVATRSGDPV
     ANAVADMLRE NRSLQSLNIE SNFISSTGLM AVLKAVRENA TLTELRVDNQ RQWPGDAVEM
     EMATVLEQCP SIVRFGYHFT QQGPRARAAQ AMTRNNELRR QQKKR