ID   TMOD4_MOUSE             Reviewed;         345 AA.
AC   Q9JLH8;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Tropomodulin-4;
DE   AltName: Full=Skeletal muscle tropomodulin;
DE            Short=Sk-Tmod;
GN   Name=Tmod4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=10662549; DOI=10.1006/geno.1999.6061;
RA   Cox P.R., Zoghbi H.Y.;
RT   "Sequencing, expression analysis, and mapping of three unique human
RT   tropomodulin genes and their mouse orthologs.";
RL   Genomics 63:97-107(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone, and Limb;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Blocks the elongation and depolymerization of the actin
CC       filaments at the pointed end. The Tmod/TM complex contributes to the
CC       formation of the short actin protofilament, which in turn defines the
CC       geometry of the membrane skeleton (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds to the N-terminus of tropomyosin and to actin.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q9NZQ9}. Note=In myofibrils with sarcomeric
CC       structure, localizes to the pointed end of actin thin filaments.
CC       {ECO:0000250|UniProtKB:Q9NZQ9}.
CC   -!- SIMILARITY: Belongs to the tropomodulin family. {ECO:0000305}.
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DR   EMBL; AF177174; AAF31673.1; -; mRNA.
DR   EMBL; BC068020; AAH68020.1; -; mRNA.
DR   CCDS; CCDS17601.1; -.
DR   RefSeq; NP_057921.1; NM_016712.3.
DR   RefSeq; XP_017175125.1; XM_017319636.1.
DR   AlphaFoldDB; Q9JLH8; -.
DR   SMR; Q9JLH8; -.
DR   STRING; 10090.ENSMUSP00000005769; -.
DR   PhosphoSitePlus; Q9JLH8; -.
DR   MaxQB; Q9JLH8; -.
DR   PaxDb; Q9JLH8; -.
DR   PRIDE; Q9JLH8; -.
DR   ProteomicsDB; 260708; -.
DR   Antibodypedia; 34056; 169 antibodies from 26 providers.
DR   DNASU; 50874; -.
DR   Ensembl; ENSMUST00000005769; ENSMUSP00000005769; ENSMUSG00000005628.
DR   Ensembl; ENSMUST00000107227; ENSMUSP00000102846; ENSMUSG00000005628.
DR   GeneID; 50874; -.
DR   KEGG; mmu:50874; -.
DR   UCSC; uc008qib.1; mouse.
DR   CTD; 29765; -.
DR   MGI; MGI:1355285; Tmod4.
DR   VEuPathDB; HostDB:ENSMUSG00000005628; -.
DR   eggNOG; KOG3735; Eukaryota.
DR   GeneTree; ENSGT00940000158734; -.
DR   HOGENOM; CLU_031052_0_1_1; -.
DR   InParanoid; Q9JLH8; -.
DR   OMA; SIIRFGY; -.
DR   OrthoDB; 1025132at2759; -.
DR   PhylomeDB; Q9JLH8; -.
DR   TreeFam; TF315841; -.
DR   Reactome; R-MMU-390522; Striated Muscle Contraction.
DR   BioGRID-ORCS; 50874; 1 hit in 72 CRISPR screens.
DR   ChiTaRS; Tmod4; mouse.
DR   PRO; PR:Q9JLH8; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q9JLH8; protein.
DR   Bgee; ENSMUSG00000005628; Expressed in muscle of arm and 122 other tissues.
DR   ExpressionAtlas; Q9JLH8; baseline and differential.
DR   Genevisible; Q9JLH8; MM.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0030016; C:myofibril; IBA:GO_Central.
DR   GO; GO:0005865; C:striated muscle thin filament; IDA:MGI.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0005523; F:tropomyosin binding; IDA:MGI.
DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR   GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR   GO; GO:0030239; P:myofibril assembly; IBA:GO_Central.
DR   GO; GO:0051694; P:pointed-end actin filament capping; IEA:InterPro.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR004934; TMOD.
DR   InterPro; IPR030129; TMOD4.
DR   PANTHER; PTHR10901; PTHR10901; 1.
DR   PANTHER; PTHR10901:SF9; PTHR10901:SF9; 1.
DR   Pfam; PF03250; Tropomodulin; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..345
FT                   /note="Tropomodulin-4"
FT                   /id="PRO_0000186137"
FT   REGION          40..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          326..345
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  39261 MW;  5C19ED96398F8A54 CRC64;
     MSSYQKELEK YRDIDEDEIL RTLSPEELEQ LDCELQEMDP ENMLLPAGLR QRDQTKKSPT
     GPLDRDALLQ YLEQQALEVK ERDDLVPYTG EKKGKPFIQP KREIPAQEQI TLEPELEEAL
     SHATDAEMCD IAAILGMYTL MSNKQYYDAI CSGEICNTEG ISSVVQPDKY KPVPDEPPNP
     TNIEEMLKRV RSNDKELEEV NLNNIQDIPI PVLSDLCEAM KTNTYVRSFS LVATKSGDPI
     ANAVADMLRE NRSLQSLNIE SNFISSTGLM AVLKAVRENA TLTELRVDNQ RQWPGDAVEM
     EMATVLEQCP SIVRFGYHFT QQGPRARAAH AMTRNNELRR QQKKR