TMOT_PSEME
ID TMOT_PSEME Reviewed; 220 AA.
AC Q8KR08;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Response regulator protein TmoT;
GN Name=tmoT;
OS Pseudomonas mendocina.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=300;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND GENE NAME.
RC STRAIN=KR1;
RX PubMed=12446657; DOI=10.1128/jb.184.24.7062-7067.2002;
RA Ramos-Gonzalez M.I., Olson M., Gatenby A.A., Mosqueda G., Manzanera M.,
RA Campos M.J., Vichez S., Ramos J.L.;
RT "Cross-regulation between a novel two-component signal transduction system
RT for catabolism of toluene in Pseudomonas mendocina and the TodST system
RT from Pseudomonas putida.";
RL J. Bacteriol. 184:7062-7067(2002).
RN [2]
RP FUNCTION IN TOLUENE DEGRADATION.
RC STRAIN=KR1;
RX PubMed=22212183; DOI=10.1111/j.1751-7915.2011.00322.x;
RA Silva-Jimenez H., Garcia-Fontana C., Cadirci B.H., Ramos-Gonzalez M.I.,
RA Ramos J.L., Krell T.;
RT "Study of the TmoS/TmoT two-component system: towards the functional
RT characterization of the family of TodS/TodT like systems.";
RL Microb. Biotechnol. 5:489-500(2012).
CC -!- FUNCTION: Member of the two-component regulatory system TmoS/TmoT
CC involved in the regulation of toluene degradation. Induces expression
CC of tmoX operon. {ECO:0000269|PubMed:12446657,
CC ECO:0000269|PubMed:22212183}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- PTM: Phosphorylated by TmoS. {ECO:0000250}.
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DR EMBL; AY052500; AAL13333.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8KR08; -.
DR SMR; Q8KR08; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1..220
FT /note="Response regulator protein TmoT"
FT /id="PRO_0000423592"
FT DOMAIN 21..135
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DOMAIN 151..216
FT /note="HTH luxR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT DNA_BIND 175..194
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT MOD_RES 70
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 220 AA; 24583 MW; 395AA7FC58F6CEE0 CRC64;
MFLRKYPGQL GRQHMNDQES VIYIVDDDNA VLEALSSLVR SIGLRVKCFS SATAFLNDVG
QLACGCLILD VRMPEMSGLD VQRKLAELGE QIPIIFISGH GDIPMAVKAI KAGAIDFFTK
PFREEDLLGA IRTALKLAPQ QKENAPQISE LKASYESLSK REQQVLKFVL QGFLNKQTAL
ELDISEATVK VHRHNIMKKM KVSSVQDLVR VTERLKDSLK
