ID   TMPA_TREPH              Reviewed;         344 AA.
AC   P29721;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Treponemal membrane protein A;
DE   AltName: Full=Antigen TmpA;
DE   AltName: Full=Membrane protein A;
DE   Flags: Precursor;
GN   Name=tmpA;
OS   Treponema phagedenis.
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=162;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Kazan 5;
RX   PubMed=1894368; DOI=10.1128/iai.59.10.3685-3693.1991;
RA   Yelton D.B., Limberger R.J., Curci K., Malinosky-Rummell F., Sliviensky L.,
RA   Schouls L.M., van Embden J.D.A., Charon N.W.;
RT   "Treponema phagedenis encodes and expresses homologs of the Treponema
RT   pallidum TmpA and TmpB proteins.";
RL   Infect. Immun. 59:3685-3693(1991).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor.
CC   -!- SIMILARITY: To T.pallidum TmpA. {ECO:0000305}.
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DR   EMBL; M58475; AAA27482.1; -; Genomic_DNA.
DR   PIR; A43592; A43592.
DR   AlphaFoldDB; P29721; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000305"
FT   CHAIN           22..344
FT                   /note="Treponemal membrane protein A"
FT                   /id="PRO_0000018198"
FT   REGION          257..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..281
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           22
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           22
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   344 AA;  37715 MW;  474833CC19B942FD CRC64;
     MKLKSLVFSL SALFLVLGFT GCKSKAQAKA EQEAQERKAF MAENAKIEKR LMQAKNAATE
     AEANVYYPEK FAQIEDLEKQ SSEAKEQDDL KKANSLGSAA ADKYETLANK MKIANQRSKI
     EANKLAKYDE ESYRLGEEAE KKIDGLYKSD SVAALQTSNE SLMYYNKVID AGYKSLSQDA
     KKTADDAKAA LTAVKVAASL KPQQEEADGI YAKAEEAENS AQYEQSYGGY TSAAQAYNDL
     TQIIKAKRLE AQKAMQAAKT KQELSAKLAN EADKESPLPE NAEGFSKEPI EVEPLPTDVL
     NAPQDEKAEE TVPVEEMNEN SSEEVNGNAE KIESTEEPIE GGVQ