ID   TMPB_TREPA              Reviewed;         325 AA.
AC   P19649;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 2.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=Treponemal membrane protein B;
DE   AltName: Full=Antigen TmpB;
DE   Flags: Precursor;
GN   Name=tmpB; OrderedLocusNames=TP_0769;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=1894368; DOI=10.1128/iai.59.10.3685-3693.1991;
RA   Yelton D.B., Limberger R.J., Curci K., Malinosky-Rummell F., Sliviensky L.,
RA   Schouls L.M., van Embden J.D.A., Charon N.W.;
RT   "Treponema phagedenis encodes and expresses homologs of the Treponema
RT   pallidum TmpA and TmpB proteins.";
RL   Infect. Immun. 59:3685-3693(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.
RX   PubMed=3922944; DOI=10.1128/jb.162.3.1227-1237.1985;
RA   Hansen E.B., Pedersen P.E., Schouls L.M., Severin E., van Embden J.D.A.;
RT   "Genetic characterization and partial sequence determination of a Treponema
RT   pallidum operon expressing two immunogenic membrane proteins in Escherichia
RT   coli.";
RL   J. Bacteriol. 162:1227-1237(1985).
CC   -!- FUNCTION: Tmp may serve as a porin or transport protein for large
CC       molecules.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: To T.phagedenis TmpB. {ECO:0000305}.
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DR   EMBL; M58562; AAA27479.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65737.1; -; Genomic_DNA.
DR   EMBL; M10931; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; F71283; F71283.
DR   RefSeq; WP_010882214.1; NC_000919.1.
DR   AlphaFoldDB; P19649; -.
DR   STRING; 243276.TPANIC_0769; -.
DR   PRIDE; P19649; -.
DR   EnsemblBacteria; AAC65737; AAC65737; TP_0769.
DR   GeneID; 57879606; -.
DR   KEGG; tpa:TP_0769; -.
DR   eggNOG; COG1652; Bacteria.
DR   HOGENOM; CLU_042249_0_0_12; -.
DR   OMA; YTVRPWA; -.
DR   OrthoDB; 1649981at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Reference proteome; Repeat; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..325
FT                   /note="Treponemal membrane protein B"
FT                   /id="PRO_0000022559"
FT   REPEAT          159..166
FT                   /note="EAARKAAE"
FT   REPEAT          167..189
FT                   /note="ARKLEEQRIAAQKAQEERKRAEE"
FT   REPEAT          190..197
FT                   /note="EAARKAAE"
FT   REPEAT          198..220
FT                   /note="ARKLEEQRIAAQKAQEERKRAEE"
FT   REPEAT          221..228
FT                   /note="EAARKAAE"
FT   REPEAT          229..236
FT                   /note="EAARKAEE"
FT   REGION          176..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   325 AA;  36961 MW;  31B479986D4A3C71 CRC64;
     MKTRNFSLVS ALYVLLGVPL FVSAASYDDN EFSRKSRAYS ELAEKTYDAG EYDVSAEYAR
     LAEDFAQKSS VYIKETMART TAEDAMNAAR TRHAWAKNER IDRAYPTEYL LASEAIKTGG
     LAFDSKQYDV ALTWARKALD ALKNVKPESQ LLAKAAKEEA ARKAAEARKL EEQRIAAQKA
     QEERKRAEEE AARKAAEARK LEEQRIAAQK AQEERKRAEE EAARKAAEEA ARKAEELEKG
     RVLPAQYKVT TWSIDRECFW NIAKNPAVYG NPFLWKKLYE ANKDKIPQSK NPNWVEPETV
     LVIPSLKGEE REGLYEPNVK YRPLP