ID   TMPPE_BOVIN             Reviewed;         444 AA.
AC   A5PJK1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Transmembrane protein with metallophosphoesterase domain;
DE            EC=3.1.-.-;
GN   Name=TMPPE;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250};
CC       Note=Binds 2 divalent metal cations. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC       LOC643853 family. {ECO:0000305}.
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DR   EMBL; BC142143; AAI42144.1; -; mRNA.
DR   RefSeq; NP_001093181.1; NM_001099711.1.
DR   RefSeq; XP_005222530.1; XM_005222473.3.
DR   RefSeq; XP_005222531.1; XM_005222474.3.
DR   AlphaFoldDB; A5PJK1; -.
DR   SMR; A5PJK1; -.
DR   GeneID; 527730; -.
DR   KEGG; bta:527730; -.
DR   CTD; 643853; -.
DR   InParanoid; A5PJK1; -.
DR   OrthoDB; 1154756at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Membrane; Metal-binding; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..444
FT                   /note="Transmembrane protein with metallophosphoesterase
FT                   domain"
FT                   /id="PRO_0000322115"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         214
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         216
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         246
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         246
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         277
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         382
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         384
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   444 AA;  48646 MW;  585697E5BB0C2347 CRC64;
     MAIFRQLSLG AKAALAAGTV FVSMIVSRSY LAESLEFRAW RCLFRLQLAL FVNSLMLLGS
     IYIWRSTVSN LRHSPAAESA CFQLWKMVVA AFLALAHSSF FTMIFLVAEE PYLFSLVAYT
     CLGAYVIMLC FLCVLSGMEQ AYQLLAWRAG RAVGSLDKTR KLALRPALAV MVTTVLSVVG
     LLNAAQPPAV TTVEVPVHRL PPSMNSLKIV LLSDIHLGPT VGRTKMDMFV RMVNTLEPDV
     TVIVGDLCDS EASVLRTAVA PLGQLRSRLG TYFVTGNHEY YTSDVSNWFA LLMSLNVQPL
     HNENVRISAT GAHREDDDWI CLAGVDDIEA NILHYTGHGM DLEKALEGCS PDHPTILLAH
     QPLAAKRALQ ARPDINLILS GHTHAGQIFP LNVAAYLLNP FFAGLYQVAE TTFVYVSPGT
     AYYGIPMRLG SRAEITQLIL QAAP