ID   TMPPE_DANRE             Reviewed;         437 AA.
AC   Q08BG1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Transmembrane protein with metallophosphoesterase domain;
DE            EC=3.1.-.-;
GN   Name=tmppe; ORFNames=zgc:153790;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250};
CC       Note=Binds 2 divalent metal cations. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC       LOC643853 family. {ECO:0000305}.
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DR   EMBL; BC124738; AAI24739.1; -; mRNA.
DR   RefSeq; NP_001073512.1; NM_001080043.1.
DR   AlphaFoldDB; Q08BG1; -.
DR   STRING; 7955.ENSDARP00000116950; -.
DR   PaxDb; Q08BG1; -.
DR   GeneID; 569483; -.
DR   KEGG; dre:569483; -.
DR   CTD; 643853; -.
DR   ZFIN; ZDB-GENE-061013-104; tmppe.
DR   eggNOG; ENOG502QRHG; Eukaryota.
DR   InParanoid; Q08BG1; -.
DR   OrthoDB; 1154756at2759; -.
DR   PhylomeDB; Q08BG1; -.
DR   PRO; PR:Q08BG1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Membrane; Metal-binding; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..437
FT                   /note="Transmembrane protein with metallophosphoesterase
FT                   domain"
FT                   /id="PRO_0000322117"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   BINDING         211
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         213
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         243
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         243
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         274
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         376
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         378
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   437 AA;  48410 MW;  BD0FCC73471E4367 CRC64;
     MFGFGRLSAE GKVGIASGVV FFSMLISRTL ISERVDKGTR ALLFRVQFLL FINSLLLLGS
     LYLWKRVVKR LCGARAAPSV PQRCWRIIVL LFLALVHGSY LCMFFLVDTE PHWLSLLSFS
     CLGVYVILLF FLFVFGCLNR LGKLLSRSRS AEEAVASGSF RQTVLALIIT AVLAVYGLVN
     AAQPPKVVDV EIPVEKLPES LNGLRLVLLS DIHLGPTVGR SKLQRIVSMV NELNPDVVVI
     VGDLTDSQVS RLRSAAEPLG QMKPRLGSYF ATGNHDYYTA DVEGWFELLH SMGIEALHNS
     HAKVFRPERT EDWICLAGID DLEARMLRYP GHGMDVEKAL NGCTTEGPII LLAHQPHAAK
     QALQQRPDIS LVLSGHTHAG QLFPLTILAF LMNPFFCGLY RVSEHTMVYV TPGTGYYGIP
     MRIASRSEIT NIVLKQA