TMPPE_HUMAN
ID TMPPE_HUMAN Reviewed; 453 AA.
AC Q6ZT21; B2RNG5; Q6ZRG1;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Transmembrane protein with metallophosphoesterase domain;
DE EC=3.1.-.-;
GN Name=TMPPE;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000250};
CC Note=Binds 2 divalent metal cations. {ECO:0000250};
CC -!- INTERACTION:
CC Q6ZT21; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-11724433, EBI-11522760;
CC Q6ZT21; P07307-3: ASGR2; NbExp=3; IntAct=EBI-11724433, EBI-12808270;
CC Q6ZT21; P11912: CD79A; NbExp=3; IntAct=EBI-11724433, EBI-7797864;
CC Q6ZT21; Q8NHS1: CLDND2; NbExp=3; IntAct=EBI-11724433, EBI-11959453;
CC Q6ZT21; P58418: CLRN1; NbExp=3; IntAct=EBI-11724433, EBI-17274839;
CC Q6ZT21; P34972: CNR2; NbExp=3; IntAct=EBI-11724433, EBI-2835940;
CC Q6ZT21; P49447: CYB561; NbExp=3; IntAct=EBI-11724433, EBI-8646596;
CC Q6ZT21; Q9Y3D6: FIS1; NbExp=3; IntAct=EBI-11724433, EBI-3385283;
CC Q6ZT21; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-11724433, EBI-713304;
CC Q6ZT21; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-11724433, EBI-13345167;
CC Q6ZT21; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-11724433, EBI-725665;
CC Q6ZT21; P48051: KCNJ6; NbExp=3; IntAct=EBI-11724433, EBI-12017638;
CC Q6ZT21; P26715: KLRC1; NbExp=3; IntAct=EBI-11724433, EBI-9018187;
CC Q6ZT21; Q68G75: LEMD1; NbExp=3; IntAct=EBI-11724433, EBI-12268900;
CC Q6ZT21; P11836: MS4A1; NbExp=3; IntAct=EBI-11724433, EBI-2808234;
CC Q6ZT21; Q9Y342: PLLP; NbExp=3; IntAct=EBI-11724433, EBI-3919291;
CC Q6ZT21; Q8TBJ4: PLPPR1; NbExp=3; IntAct=EBI-11724433, EBI-18063495;
CC Q6ZT21; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-11724433, EBI-8652812;
CC Q6ZT21; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-11724433, EBI-7545592;
CC Q6ZT21; Q96HR9-2: REEP6; NbExp=3; IntAct=EBI-11724433, EBI-14065960;
CC Q6ZT21; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-11724433, EBI-10192441;
CC Q6ZT21; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-11724433, EBI-10244780;
CC Q6ZT21; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-11724433, EBI-17247926;
CC Q6ZT21; Q8TD22: SFXN5; NbExp=3; IntAct=EBI-11724433, EBI-17274136;
CC Q6ZT21; Q96DU3: SLAMF6; NbExp=3; IntAct=EBI-11724433, EBI-14058448;
CC Q6ZT21; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-11724433, EBI-9978441;
CC Q6ZT21; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-11724433, EBI-10226799;
CC Q6ZT21; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-11724433, EBI-17280858;
CC Q6ZT21; Q13277: STX3; NbExp=3; IntAct=EBI-11724433, EBI-1394295;
CC Q6ZT21; Q9UNK0: STX8; NbExp=3; IntAct=EBI-11724433, EBI-727240;
CC Q6ZT21; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-11724433, EBI-2852148;
CC Q6ZT21; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-11724433, EBI-11988865;
CC Q6ZT21; Q15836: VAMP3; NbExp=3; IntAct=EBI-11724433, EBI-722343;
CC Q6ZT21; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-11724433, EBI-7850136;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZT21-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZT21-2; Sequence=VSP_031858;
CC -!- SIMILARITY: Belongs to the metallophosphoesterase superfamily.
CC LOC643853 family. {ECO:0000305}.
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DR EMBL; AK126979; BAC86774.1; -; mRNA.
DR EMBL; AK128242; BAC87349.1; -; mRNA.
DR EMBL; BC136872; AAI36873.1; -; mRNA.
DR EMBL; BC136873; AAI36874.1; -; mRNA.
DR CCDS; CCDS33732.1; -. [Q6ZT21-1]
DR CCDS; CCDS46786.1; -. [Q6ZT21-2]
DR RefSeq; NP_001034859.2; NM_001039770.2. [Q6ZT21-1]
DR RefSeq; NP_001129710.1; NM_001136238.1. [Q6ZT21-2]
DR AlphaFoldDB; Q6ZT21; -.
DR BioGRID; 569104; 72.
DR IntAct; Q6ZT21; 58.
DR MINT; Q6ZT21; -.
DR STRING; 9606.ENSP00000343398; -.
DR iPTMnet; Q6ZT21; -.
DR PhosphoSitePlus; Q6ZT21; -.
DR SwissPalm; Q6ZT21; -.
DR BioMuta; TMPPE; -.
DR DMDM; 190359341; -.
DR EPD; Q6ZT21; -.
DR jPOST; Q6ZT21; -.
DR MassIVE; Q6ZT21; -.
DR MaxQB; Q6ZT21; -.
DR PaxDb; Q6ZT21; -.
DR PeptideAtlas; Q6ZT21; -.
DR PRIDE; Q6ZT21; -.
DR ProteomicsDB; 68256; -. [Q6ZT21-1]
DR ProteomicsDB; 68257; -. [Q6ZT21-2]
DR Antibodypedia; 11672; 73 antibodies from 17 providers.
DR DNASU; 643853; -.
DR Ensembl; ENST00000342462.5; ENSP00000343398.4; ENSG00000188167.9. [Q6ZT21-1]
DR Ensembl; ENST00000416695.6; ENSP00000400715.2; ENSG00000188167.9. [Q6ZT21-2]
DR GeneID; 643853; -.
DR KEGG; hsa:643853; -.
DR MANE-Select; ENST00000342462.5; ENSP00000343398.4; NM_001039770.3; NP_001034859.2.
DR UCSC; uc003cfk.3; human. [Q6ZT21-1]
DR CTD; 643853; -.
DR DisGeNET; 643853; -.
DR GeneCards; TMPPE; -.
DR HGNC; HGNC:33865; TMPPE.
DR HPA; ENSG00000188167; Tissue enhanced (bone).
DR MalaCards; TMPPE; -.
DR neXtProt; NX_Q6ZT21; -.
DR OpenTargets; ENSG00000188167; -.
DR PharmGKB; PA164726564; -.
DR VEuPathDB; HostDB:ENSG00000188167; -.
DR eggNOG; ENOG502QRHG; Eukaryota.
DR GeneTree; ENSGT00390000010260; -.
DR HOGENOM; CLU_025443_6_0_1; -.
DR InParanoid; Q6ZT21; -.
DR OMA; AESTCFQ; -.
DR OrthoDB; 1154756at2759; -.
DR PhylomeDB; Q6ZT21; -.
DR TreeFam; TF315106; -.
DR PathwayCommons; Q6ZT21; -.
DR SignaLink; Q6ZT21; -.
DR BioGRID-ORCS; 643853; 11 hits in 1071 CRISPR screens.
DR GenomeRNAi; 643853; -.
DR Pharos; Q6ZT21; Tdark.
DR PRO; PR:Q6ZT21; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6ZT21; protein.
DR Bgee; ENSG00000188167; Expressed in monocyte and 109 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Hydrolase; Membrane; Metal-binding;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..453
FT /note="Transmembrane protein with metallophosphoesterase
FT domain"
FT /id="PRO_0000322116"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT BINDING 214
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 216
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 246
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 246
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 277
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 391
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 393
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..137
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_031858"
FT CONFLICT 209
FT /note="I -> V (in Ref. 1; BAC86774)"
FT /evidence="ECO:0000305"
FT CONFLICT 266
FT /note="H -> R (in Ref. 1; BAC86774)"
FT /evidence="ECO:0000305"
FT CONFLICT 347
FT /note="H -> R (in Ref. 1; BAC87349)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 453 AA; 49453 MW; F5455B6801793D68 CRC64;
MAIFRQLSLG AKATLAAVTV FVSMIASRSY LAESLELRAW RWLLRLQLAL FVNSLLLIGS
LYIWRSTVSN LCHSPAAEST CFQLWKVVVL AFLALAHSSF FTMFFLVAEE PYLFSLAAYS
CLGAYIIMLF FLFILSGMEQ AYQLLAWRSG RVVGSLEKTR KLVLRPALAV GVTAVLSVAG
ILNAAQPPAV KTVEVPIHQL PASMNNLKIV LLSDIHLGPT VGRTKMEMFV RMVNVLEPDI
TVIVGDLSDS EASVLRTAVA PLGQLHSHLG AYFVTGNHEY YTSDVSNWFA LLESLHVQPL
HNENVKISAT RAQRGGGGSG SGSEDEDWIC LAGVDDIEAD ILHYSGHGMD LDKALEGCSP
DHTIILLAHQ PLAAKRALQA RPDINLILSG HTHAGQIFPL NVAAYLLNPF FAGLYQVAQA
TFVYVSPGTA YYGIPMRLGS RAEITELILQ RSP
