BTBDH_HUMAN
ID BTBDH_HUMAN Reviewed; 478 AA.
AC A6NE02;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=BTB/POZ domain-containing protein 17;
DE AltName: Full=Galectin-3-binding protein-like;
DE Flags: Precursor;
GN Name=BTBD17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AC103809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471099; EAW89155.1; -; Genomic_DNA.
DR CCDS; CCDS32719.1; -.
DR RefSeq; NP_001073935.1; NM_001080466.1.
DR AlphaFoldDB; A6NE02; -.
DR SMR; A6NE02; -.
DR BioGRID; 132681; 5.
DR STRING; 9606.ENSP00000364515; -.
DR GlyGen; A6NE02; 3 sites.
DR iPTMnet; A6NE02; -.
DR PhosphoSitePlus; A6NE02; -.
DR BioMuta; BTBD17; -.
DR MassIVE; A6NE02; -.
DR PaxDb; A6NE02; -.
DR PeptideAtlas; A6NE02; -.
DR PRIDE; A6NE02; -.
DR ProteomicsDB; 952; -.
DR Antibodypedia; 19431; 84 antibodies from 16 providers.
DR DNASU; 388419; -.
DR Ensembl; ENST00000375366.4; ENSP00000364515.3; ENSG00000204347.4.
DR GeneID; 388419; -.
DR KEGG; hsa:388419; -.
DR MANE-Select; ENST00000375366.4; ENSP00000364515.3; NM_001080466.2; NP_001073935.1.
DR UCSC; uc002jkn.3; human.
DR CTD; 388419; -.
DR GeneCards; BTBD17; -.
DR HGNC; HGNC:33758; BTBD17.
DR HPA; ENSG00000204347; Tissue enriched (brain).
DR neXtProt; NX_A6NE02; -.
DR OpenTargets; ENSG00000204347; -.
DR PharmGKB; PA162377627; -.
DR VEuPathDB; HostDB:ENSG00000204347; -.
DR eggNOG; KOG2075; Eukaryota.
DR GeneTree; ENSGT00950000182983; -.
DR HOGENOM; CLU_044480_0_0_1; -.
DR InParanoid; A6NE02; -.
DR OMA; YLAFQFH; -.
DR OrthoDB; 1174057at2759; -.
DR PhylomeDB; A6NE02; -.
DR TreeFam; TF331368; -.
DR PathwayCommons; A6NE02; -.
DR SignaLink; A6NE02; -.
DR BioGRID-ORCS; 388419; 13 hits in 1096 CRISPR screens.
DR ChiTaRS; BTBD17; human.
DR GenomeRNAi; 388419; -.
DR Pharos; A6NE02; Tdark.
DR PRO; PR:A6NE02; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; A6NE02; protein.
DR Bgee; ENSG00000204347; Expressed in ventricular zone and 42 other tissues.
DR Genevisible; A6NE02; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0045071; P:negative regulation of viral genome replication; ISS:UniProtKB.
DR GO; GO:0009615; P:response to virus; ISS:UniProtKB.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..478
FT /note="BTB/POZ domain-containing protein 17"
FT /id="PRO_0000340704"
FT DOMAIN 63..132
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 169..269
FT /note="BACK"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 478 AA; 52471 MW; A0D574BECE1A0D05 CRC64;
MPRRGYSKPG SWGSFWAMLT LVGLVTHAAQ RADVGGEAAG TSINHSQAVL QRLQELLRQG
NASDVVLRVQ AAGTDEVRVF HAHRLLLGLH SELFLELLSN QSEAVLQEPQ DCAAVFDKFI
RYLYCGELTV LLTQAIPLHR LATKYGVSSL QRGVADYMRA HLAGGAGPAV GWYHYAVGTG
DEALRESCLQ FLAWNLSAVA ASTEWGAVSP ELLWQLLQRS DLVLQDELEL FHALEAWLGR
ARPPPAVAER ALRAIRYPMI PPAQLFQLQA RSAALARHGP AVADLLLQAY QFHAASPLHY
AKFFDVNGSA FLPRNYLAPA WGAPWVINNP ARDDRSTSFQ TQLGPSGHDA GRRVTWNVLF
SPRWLPVSLR PVYADAAGTA LPAARPEDGR PRLVVTPASS GGDAAGVSFQ KTVLVGARQQ
GRLLVRHAYS FHQSSEEAGD FLAHADLQRR NSEYLVENAL HLHLIVKPVY HTLIRTPK
