TMPS7_HUMAN
ID TMPS7_HUMAN Reviewed; 843 AA.
AC Q7RTY8; C9J8P7; E9PAS3; Q17RH4;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 3.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Transmembrane protease serine 7;
DE EC=3.4.21.-;
DE AltName: Full=Matriptase-3;
GN Name=TMPRSS7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=12838346; DOI=10.1038/nrg1111;
RA Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C.;
RT "Human and mouse proteases: a comparative genomic approach.";
RL Nat. Rev. Genet. 4:544-558(2003).
RN [5]
RP TISSUE SPECIFICITY, AND HETERODIMER WITH SERPINA5.
RX PubMed=15853774; DOI=10.1042/bj20050299;
RA Szabo R., Netzel-Arnett S., Hobson J.P., Antalis T.M., Bugge T.H.;
RT "Matriptase-3 is a novel phylogenetically preserved membrane-anchored
RT serine protease with broad serpin reactivity.";
RL Biochem. J. 390:231-242(2005).
CC -!- FUNCTION: Serine protease which preferentially hydrolyzes peptides with
CC Arg at the P1 position. {ECO:0000250}.
CC -!- SUBUNIT: Forms a heterodimer with SERPINA5.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II
CC membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7RTY8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7RTY8-2; Sequence=VSP_040772, VSP_040773, VSP_040774;
CC Name=3;
CC IsoId=Q7RTY8-3; Sequence=VSP_040771;
CC -!- TISSUE SPECIFICITY: Expressed in brain, ovary, testis, salivary gland,
CC trachea and lung. {ECO:0000269|PubMed:15853774}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00274}.
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DR EMBL; AC015778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC024887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK131211; BAD18401.1; -; mRNA.
DR EMBL; BC117322; AAI17323.1; -; mRNA.
DR EMBL; BN000125; CAD67577.1; -; mRNA.
DR CCDS; CCDS43129.2; -. [Q7RTY8-2]
DR RefSeq; NP_001036040.2; NM_001042575.2. [Q7RTY8-2]
DR AlphaFoldDB; Q7RTY8; -.
DR SMR; Q7RTY8; -.
DR BioGRID; 131324; 1.
DR STRING; 9606.ENSP00000478830; -.
DR MEROPS; S01.072; -.
DR iPTMnet; Q7RTY8; -.
DR PhosphoSitePlus; Q7RTY8; -.
DR BioMuta; TMPRSS7; -.
DR DMDM; 327478556; -.
DR MassIVE; Q7RTY8; -.
DR PaxDb; Q7RTY8; -.
DR PeptideAtlas; Q7RTY8; -.
DR PRIDE; Q7RTY8; -.
DR ProteomicsDB; 68937; -. [Q7RTY8-1]
DR ProteomicsDB; 68938; -. [Q7RTY8-2]
DR ProteomicsDB; 68939; -. [Q7RTY8-3]
DR Antibodypedia; 52124; 119 antibodies from 17 providers.
DR DNASU; 344805; -.
DR Ensembl; ENST00000419127.5; ENSP00000411645.1; ENSG00000176040.13. [Q7RTY8-2]
DR Ensembl; ENST00000452346.6; ENSP00000398236.2; ENSG00000176040.13. [Q7RTY8-1]
DR Ensembl; ENST00000617607.4; ENSP00000478830.1; ENSG00000176040.13. [Q7RTY8-2]
DR GeneID; 344805; -.
DR KEGG; hsa:344805; -.
DR MANE-Select; ENST00000452346.7; ENSP00000398236.2; NM_001395507.1; NP_001382436.1.
DR UCSC; uc010hqb.3; human. [Q7RTY8-1]
DR CTD; 344805; -.
DR DisGeNET; 344805; -.
DR GeneCards; TMPRSS7; -.
DR HGNC; HGNC:30846; TMPRSS7.
DR HPA; ENSG00000176040; Tissue enhanced (testis).
DR neXtProt; NX_Q7RTY8; -.
DR OpenTargets; ENSG00000176040; -.
DR PharmGKB; PA134928796; -.
DR VEuPathDB; HostDB:ENSG00000176040; -.
DR eggNOG; KOG3627; Eukaryota.
DR GeneTree; ENSGT00940000160085; -.
DR HOGENOM; CLU_006842_19_3_1; -.
DR InParanoid; Q7RTY8; -.
DR OMA; KPACNTS; -.
DR OrthoDB; 1314811at2759; -.
DR PhylomeDB; Q7RTY8; -.
DR TreeFam; TF330647; -.
DR PathwayCommons; Q7RTY8; -.
DR BioGRID-ORCS; 344805; 12 hits in 1066 CRISPR screens.
DR GenomeRNAi; 344805; -.
DR Pharos; Q7RTY8; Tdark.
DR PRO; PR:Q7RTY8; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q7RTY8; protein.
DR Bgee; ENSG00000176040; Expressed in olfactory segment of nasal mucosa and 36 other tissues.
DR ExpressionAtlas; Q7RTY8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0008236; F:serine-type peptidase activity; ISS:UniProtKB.
DR GO; GO:0006508; P:proteolysis; ISS:UniProtKB.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00112; LDLa; 2.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; -; 2.
DR Gene3D; 2.60.120.290; -; 2.
DR Gene3D; 3.30.70.960; -; 1.
DR Gene3D; 4.10.400.10; -; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR Pfam; PF01390; SEA; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF49854; SSF49854; 2.
DR SUPFAM; SSF50494; SSF50494; 1.
DR SUPFAM; SSF57424; SSF57424; 3.
DR SUPFAM; SSF82671; SSF82671; 1.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
DR PROSITE; PS50024; SEA; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Hydrolase; Membrane; Protease; Reference proteome; Repeat; Serine protease;
KW Signal-anchor; Transmembrane; Transmembrane helix; Zymogen.
FT CHAIN 1..843
FT /note="Transmembrane protease serine 7"
FT /id="PRO_0000027859"
FT TOPO_DOM 1..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..843
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 106..234
FT /note="SEA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT DOMAIN 247..360
FT /note="CUB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 365..481
FT /note="CUB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00059"
FT DOMAIN 483..519
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 517..554
FT /note="LDL-receptor class A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 558..595
FT /note="LDL-receptor class A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 606..840
FT /note="Peptidase S1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT REGION 27..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..53
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 646
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 694
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 790
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT DISULFID 247..273
FT /evidence="ECO:0000250"
FT DISULFID 299..322
FT /evidence="ECO:0000250"
FT DISULFID 365..396
FT /evidence="ECO:0000250"
FT DISULFID 484..496
FT /evidence="ECO:0000250"
FT DISULFID 491..509
FT /evidence="ECO:0000250"
FT DISULFID 503..518
FT /evidence="ECO:0000250"
FT DISULFID 525..544
FT /evidence="ECO:0000250"
FT DISULFID 538..553
FT /evidence="ECO:0000250"
FT DISULFID 559..571
FT /evidence="ECO:0000250"
FT DISULFID 566..585
FT /evidence="ECO:0000250"
FT DISULFID 579..594
FT /evidence="ECO:0000250"
FT DISULFID 631..647
FT /evidence="ECO:0000250"
FT DISULFID 730..796
FT /evidence="ECO:0000250"
FT DISULFID 762..775
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..271
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_040771"
FT VAR_SEQ 1..112
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040772"
FT VAR_SEQ 166
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040773"
FT VAR_SEQ 231..243
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_040774"
FT CONFLICT 816
FT /note="S -> C (in Ref. 2; BAD18401 and 3; AAI17323)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 843 AA; 94415 MW; 8D97E984FD87934C CRC64;
MDKENSDVSA APADLKISNI SVQVVSAQKK LPVRRPPLPG RRLPLPGRRP PQRPIGKAKP
KKQSKKKVPF WNVQNKIILF TVFLFILAVI AWTLLWLYIS KTESKDAFYF AGMFRITNIE
FLPEYRQKES REFLSVSRTV QQVINLVYTT SAFSKFYEQS VVADVSSNNK GGLLVHFWIV
FVMPRAKGHI FCEDCVAAIL KDSIQTSIIN RTSVGSLQGL AVDMDSVVLN AGLRSDYSST
IGSDKGCSQY FYAEHLSLHY PLEISAASGR LMCHFKLVAI VGYLIRLSIK SIQIEADNCV
TDSLTIYDSL LPIRSSILYR ICEPTRTLMS FVSTNNLMLV TFKSPHIRRL SGIRAYFEVI
PEQKCENTVL VKDITGFEGK ISSPYYPSYY PPKCKCTWKF QTSLSTLGIA LKFYNYSITK
KSMKGCEHGW WEINEHMYCG SYMDHQTIFR VPSPLVHIQL QCSSRLSDKP LLAEYGSYNI
SQPCPVGSFR CSSGLCVPQA QRCDGVNDCF DESDELFCVS PQPACNTSSF RQHGPLICDG
FRDCENGRDE QNCTQSIPCN NRTFKCGNDI CFRKQNAKCD GTVDCPDGSD EEGCTCSRSS
SALHRIIGGT DTLEGGWPWQ VSLHFVGSAY CGASVISREW LLSAAHCFHG NRLSDPTPWT
AHLGMYVQGN AKFVSPVRRI VVHEYYNSQT FDYDIALLQL SIAWPETLKQ LIQPICIPPT
GQRVRSGEKC WVTGWGRRHE ADNKGSLVLQ QAEVELIDQT LCVSTYGIIT SRMLCAGIMS
GKRDACKGDS GGPLSCRRKS DGKWILTGIV SWGHGSGRPN FPGVYTRVSN FVPWIHKYVP
SLL
