BTBDH_MOUSE
ID BTBDH_MOUSE Reviewed; 478 AA.
AC Q9DB72;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=BTB/POZ domain-containing protein 17;
DE AltName: Full=Galectin-3-binding protein-like;
DE Flags: Precursor;
GN Name=Btbd17;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Cerebellum, Corpora quadrigemina, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AK005160; BAB23851.1; -; mRNA.
DR EMBL; AK032100; BAC27699.1; -; mRNA.
DR EMBL; AK046050; BAC32582.1; -; mRNA.
DR EMBL; AL663079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC122876; AAI22877.1; -; mRNA.
DR CCDS; CCDS25610.1; -.
DR RefSeq; NP_082331.1; NM_028055.4.
DR AlphaFoldDB; Q9DB72; -.
DR SMR; Q9DB72; -.
DR BioGRID; 215093; 1.
DR IntAct; Q9DB72; 1.
DR MINT; Q9DB72; -.
DR STRING; 10090.ENSMUSP00000000206; -.
DR GlyConnect; 2162; 22 N-Linked glycans (4 sites).
DR GlyGen; Q9DB72; 5 sites, 22 N-linked glycans (4 sites).
DR iPTMnet; Q9DB72; -.
DR PhosphoSitePlus; Q9DB72; -.
DR MaxQB; Q9DB72; -.
DR PaxDb; Q9DB72; -.
DR PeptideAtlas; Q9DB72; -.
DR PRIDE; Q9DB72; -.
DR ProteomicsDB; 273711; -.
DR Antibodypedia; 19431; 84 antibodies from 16 providers.
DR DNASU; 72014; -.
DR Ensembl; ENSMUST00000000206; ENSMUSP00000000206; ENSMUSG00000000202.
DR GeneID; 72014; -.
DR KEGG; mmu:72014; -.
DR UCSC; uc007mfr.1; mouse.
DR CTD; 388419; -.
DR MGI; MGI:1919264; Btbd17.
DR VEuPathDB; HostDB:ENSMUSG00000000202; -.
DR eggNOG; KOG2075; Eukaryota.
DR GeneTree; ENSGT00950000182983; -.
DR HOGENOM; CLU_044480_0_0_1; -.
DR InParanoid; Q9DB72; -.
DR OMA; YLAFQFH; -.
DR OrthoDB; 1174057at2759; -.
DR PhylomeDB; Q9DB72; -.
DR TreeFam; TF331368; -.
DR BioGRID-ORCS; 72014; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Btbd17; mouse.
DR PRO; PR:Q9DB72; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9DB72; protein.
DR Bgee; ENSMUSG00000000202; Expressed in lumbar subsegment of spinal cord and 69 other tissues.
DR Genevisible; Q9DB72; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..478
FT /note="BTB/POZ domain-containing protein 17"
FT /id="PRO_0000340705"
FT DOMAIN 63..132
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 169..269
FT /note="BACK"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 100
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 307
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 478 AA; 52602 MW; DD941DE7BB3EAB0D CRC64;
MLRKGSCKPG SWGSFWAILA LVGLVTRAAQ RADVGGEAAG TAINHSHMLL QRLQDLLRQG
NASDVILRVQ AVGTDEVRAF HTHRLLLGLH SELFRELLSN QSEVMLRESR DCAAVFDKFI
RYLYCGELTV LLAQAIPLHR LATKYRVASL QRGVADYMRA HLAGGVGPAV GWYHYAVSTG
DEALRESCLQ FLAWNLSAVA GSAEWGAVSP ELLAQLLQRS DLVLQDELEL FHALEAWLGR
ARPPPTVAER ALRAIRYPMI PPAQLFQLQA RSAALARHGP AVADLLLQAY QFHAASPLHY
AKFFHVNGSA FLPRNYLAPA WGAPWVINNP ARDDRSTSFQ TQLGPSGHDA GRRITWNVLF
SPRWLPVSLR PVYADAAGTA LPAARPEDGR PRLVVTPASS GGDAAGVSFQ KTVLVGARHQ
GRLLVRHAYS FHQSSEEAGD FLAHADLQRR NSEYLVENAL HLHLIVKPVY HTLIRTPS
