TMS1_YEAST
ID TMS1_YEAST Reviewed; 473 AA.
AC Q12116; D6VS91;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Membrane protein TMS1;
GN Name=TMS1; OrderedLocusNames=YDR105C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP GENE NAME.
RX PubMed=10637174; DOI=10.1242/jeb.203.3.447;
RA Grossman T.R., Luque J.M., Nelson N.;
RT "Identification of a ubiquitous family of membrane proteins and their
RT expression in mouse brain.";
RL J. Exp. Biol. 203:447-457(2000).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TDE1 family. {ECO:0000305}.
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DR EMBL; Z47746; CAA87681.1; -; Genomic_DNA.
DR EMBL; Z48758; CAA88659.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11951.1; -; Genomic_DNA.
DR PIR; S51256; S51256.
DR RefSeq; NP_010390.3; NM_001180413.3.
DR AlphaFoldDB; Q12116; -.
DR SMR; Q12116; -.
DR BioGRID; 32162; 150.
DR DIP; DIP-5198N; -.
DR IntAct; Q12116; 4.
DR MINT; Q12116; -.
DR STRING; 4932.YDR105C; -.
DR iPTMnet; Q12116; -.
DR PaxDb; Q12116; -.
DR PRIDE; Q12116; -.
DR EnsemblFungi; YDR105C_mRNA; YDR105C; YDR105C.
DR GeneID; 851682; -.
DR KEGG; sce:YDR105C; -.
DR SGD; S000002512; TMS1.
DR VEuPathDB; FungiDB:YDR105C; -.
DR eggNOG; KOG2592; Eukaryota.
DR GeneTree; ENSGT01030000234623; -.
DR HOGENOM; CLU_029574_2_0_1; -.
DR InParanoid; Q12116; -.
DR OMA; MEPDDKQ; -.
DR BioCyc; YEAST:G3O-29707-MON; -.
DR Reactome; R-SCE-977347; Serine biosynthesis.
DR PRO; PR:Q12116; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q12116; protein.
DR GO; GO:0000329; C:fungal-type vacuole membrane; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR005016; TDE1/TMS.
DR InterPro; IPR029559; Tms1-like.
DR PANTHER; PTHR10383; PTHR10383; 1.
DR PANTHER; PTHR10383:SF9; PTHR10383:SF9; 1.
DR Pfam; PF03348; Serinc; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..473
FT /note="Membrane protein TMS1"
FT /id="PRO_0000218972"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..38
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..81
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..118
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 139..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..194
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..246
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 247..295
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..398
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..421
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 422..435
FT /note="Vacuolar"
FT /evidence="ECO:0000255"
FT TRANSMEM 436..458
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 459..473
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 473 AA; 52230 MW; DFA9011F9D56EEDE CRC64;
MGAVISLPVS MAGSFVASCF GGCCSNLVTK TASSLGSSSL GTRLLYAVWL LLNSLISWVS
YSANKSILWP GKTCTGTGEC GFFTVHRLNF ALGCLHLILA LVLTGVKSTN DVRAALQNSW
WSLKFILYLC LIVLSFVIPN DFYIFFSKWV SVPSGAIFIL VGLILLVDFA HEWAETCISH
VESEDEDSSF WQRFLVLGTT SMYTASIIMT VVMYVMFCHQ QCNMNQTAVT VNLILTVITL
VLSVNPKIQE ANPKSGLAQS SMVSVYCTYL TMSAMSSEPD DKMCNPLVRS SGTRKFSIIL
GSLFTFIAIA YTTTRAAANS AFQGTNTNGA IYLGNDIEYE GLGGQTRNQL RYEAIKQAVE
EGSLPESALY DTAWLGTSSP TGAMDNQNDD ERTGTKYNYT LFHVIFFLAT QWIAILLTIN
VTQDDVGDFI PVGRTYFYSW VKIVSAWICY ALYGWTVVAP AIMPDRFDYE NYY
