ID   TMTX_HOTTA              Reviewed;          35 AA.
AC   Q9BN12;
DT   19-DEC-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Tamulustoxin;
DE            Short=TmTX;
OS   Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34647;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE, FUNCTION, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=11361010; DOI=10.1006/abbi.2000.2135;
RA   Strong P.N., Clark G.S., Armugam A., De-Allie F.A., Joseph J.S., Yemul V.,
RA   Deshpande J.M., Kamat R., Gadre S.V., Gopalakrishnakone P., Kini R.M.,
RA   Owen D.G., Jeyaseelan K.;
RT   "Tamulustoxin: a novel potassium channel blocker from the venom of the
RT   Indian red scorpion Mesobuthus tamulus.";
RL   Arch. Biochem. Biophys. 385:138-144(2001).
CC   -!- FUNCTION: Blocks Kv1.6/KCNA6 potassium channels.
CC       {ECO:0000269|PubMed:11361010}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=3945.7; Mass_error=0.4; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:11361010};
CC   -!- SIMILARITY: Belongs to the short scorpion toxin superfamily. Potassium
CC       channel inhibitor family. {ECO:0000305}.
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DR   EMBL; AF276224; AAK01860.1; -; mRNA.
DR   AlphaFoldDB; Q9BN12; -.
DR   SMR; Q9BN12; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019870; F:potassium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR012636; Toxin_32.
DR   Pfam; PF08120; Toxin_32; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Ion channel impairing toxin;
KW   Neurotoxin; Potassium channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated potassium channel impairing toxin.
FT   PEPTIDE         1..35
FT                   /note="Tamulustoxin"
FT                   /id="PRO_0000044932"
FT   DISULFID        2..22
FT                   /evidence="ECO:0000250"
FT   DISULFID        7..31
FT                   /evidence="ECO:0000250"
FT   DISULFID        11..33
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   35 AA;  3953 MW;  EDB505188D0EA87A CRC64;
     RCHFVVCTTD CRRNSPGTYG ECVKKEKGKE CVCKS