ID   TMUB1_DANRE             Reviewed;         292 AA.
AC   Q6P135;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Transmembrane and ubiquitin-like domain-containing protein 1;
GN   Name=tmub1; ORFNames=zgc:77146;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May contribute to the regulation of translation during cell-
CC       cycle progression. May contribute to the regulation of cell
CC       proliferation (By similarity). The membrane form is involved in sterol-
CC       regulated ubiquitination and degradation of HMG-CoA reductase HMGCR.
CC       May be involved in centrosome assembly. {ECO:0000250|UniProtKB:Q9BVT8,
CC       ECO:0000250|UniProtKB:Q9JMG3}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9JMG3,
CC       ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}.
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DR   EMBL; BC065312; AAH65312.1; -; mRNA.
DR   RefSeq; NP_998463.1; NM_213298.2.
DR   AlphaFoldDB; Q6P135; -.
DR   SMR; Q6P135; -.
DR   STRING; 7955.ENSDARP00000056641; -.
DR   PaxDb; Q6P135; -.
DR   Ensembl; ENSDART00000056642; ENSDARP00000056641; ENSDARG00000038787.
DR   GeneID; 406589; -.
DR   KEGG; dre:406589; -.
DR   CTD; 83590; -.
DR   ZFIN; ZDB-GENE-040426-2504; tmub1.
DR   eggNOG; ENOG502QU8U; Eukaryota.
DR   GeneTree; ENSGT00390000014069; -.
DR   HOGENOM; CLU_053940_0_0_1; -.
DR   InParanoid; Q6P135; -.
DR   OMA; SRYHYAQ; -.
DR   OrthoDB; 1164744at2759; -.
DR   PhylomeDB; Q6P135; -.
DR   TreeFam; TF329265; -.
DR   PRO; PR:Q6P135; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 2.
DR   Bgee; ENSDARG00000038787; Expressed in early embryo and 28 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR040352; TMUB1/2.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR14557; PTHR14557; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Nucleus; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..292
FT                   /note="Transmembrane and ubiquitin-like domain-containing
FT                   protein 1"
FT                   /id="PRO_0000370252"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          149..222
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          34..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   292 AA;  31079 MW;  630AE2AC27C6DD58 CRC64;
     MALIEGVGDE VTLLFGVVFL VLVLVLAWAS THTVEPPEHL LSPSPGASPS TETDSQEPLP
     PGNTDSSPGG VRDEDDKSEP GTEAGAAGQS ADGSRAGGGD GGLLDDAGLG SDGLRHRESA
     GPSTHPPEST PSATQPSAED AASDTHRNMV LRLKFLNDTE RTAQVNPQDT IGYIKRTYFA
     GQEHQVRLIY QGQLLQDDSQ TLASLNLADN SVLHCHISQH ATRAMPAGAR AADQVHVALN
     VGSLMVPLFV LMLSVLWYFQ IQYRQFFTAP ATASLVGITI FFSFVAFGVY RR