ID   TMUB1_XENLA             Reviewed;         308 AA.
AC   Q3KPV4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Transmembrane and ubiquitin-like domain-containing protein 1;
GN   Name=tmub1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May contribute to the regulation of translation during cell-
CC       cycle progression. May contribute to the regulation of cell
CC       proliferation (By similarity). The membrane form is involved in sterol-
CC       regulated ubiquitination and degradation of HMG-CoA reductase HMGCR.
CC       May be involved in centrosome assembly. {ECO:0000250|UniProtKB:Q9BVT8,
CC       ECO:0000250|UniProtKB:Q9JMG3}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9JMG3,
CC       ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}.
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DR   EMBL; BC106532; AAI06533.1; -; mRNA.
DR   RefSeq; NP_001089771.1; NM_001096302.1.
DR   AlphaFoldDB; Q3KPV4; -.
DR   SMR; Q3KPV4; -.
DR   DNASU; 734835; -.
DR   GeneID; 734835; -.
DR   KEGG; xla:734835; -.
DR   CTD; 734835; -.
DR   Xenbase; XB-GENE-6255012; tmub1.S.
DR   OMA; SRYHYAQ; -.
DR   OrthoDB; 1164744at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 734835; Expressed in testis and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IEA:InterPro.
DR   InterPro; IPR040352; TMUB1/2.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR14557; PTHR14557; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Nucleus; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..308
FT                   /note="Transmembrane and ubiquitin-like domain-containing
FT                   protein 1"
FT                   /id="PRO_0000370253"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          169..242
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          39..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..117
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        130..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   308 AA;  33155 MW;  8BB5E6D692FFEEDD CRC64;
     MALIEGVGDE VTVLFALVLF FMVLMLAWVS THTTERAPTH WIRPEPAQGG ASSNSQRDFH
     PGPSQTLTNA DPNSETVDSS DSTQSSREFQ NAGATPHSEV AFSSSGSTVS TGGSVEYTGA
     AADSPPDGES HPNFTVSSRD PQAGASSSLR YRGLGDGTTA QSAEEAGTIH LRLKFLNDTE
     RLVTVRLSDT IMYIKRTYFP GQELRVRLIF QGQLLRDDSQ TVSSLQLRDG SVLHCHISQH
     ASVPGVGADQ ANVPLNVGNL LVPLLFLIVM LLWYCQFQYP SLFTGTATAC LGGFTLLISA
     IAFSSYHR