ID   TMUB1_XENTR             Reviewed;         312 AA.
AC   Q4V9Y1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Transmembrane and ubiquitin-like domain-containing protein 1;
GN   Name=tmub1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May contribute to the regulation of translation during cell-
CC       cycle progression. May contribute to the regulation of cell
CC       proliferation (By similarity). The membrane form is involved in sterol-
CC       regulated ubiquitination and degradation of HMG-CoA reductase HMGCR.
CC       May be involved in centrosome assembly. {ECO:0000250|UniProtKB:Q9BVT8,
CC       ECO:0000250|UniProtKB:Q9JMG3}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9JMG3,
CC       ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH96635.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC096635; AAH96635.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q4V9Y1; -.
DR   SMR; Q4V9Y1; -.
DR   STRING; 8364.ENSXETP00000006683; -.
DR   PaxDb; Q4V9Y1; -.
DR   eggNOG; ENOG502QU8U; Eukaryota.
DR   InParanoid; Q4V9Y1; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR040352; TMUB1/2.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR14557; PTHR14557; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Nucleus; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Transmembrane and ubiquitin-like domain-containing
FT                   protein 1"
FT                   /id="PRO_0000370254"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          165..238
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          53..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          108..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          235..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..161
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  34295 MW;  E7CE80040170ABB2 CRC64;
     MIEGLGDEVT VAVGLFILLL AITLAWLSTY VAEGSDPLLG SLIPTGRRDP LLVLSNPVPA
     SPEPQRPAEA QAEKPEEGEQ DPGGEQEAGS ENANLDQMLD IQGVSKRSHA VPPLREEDGT
     EQDVTQEDDK EAESPLIVGR KIEQEEEKPL AKEGMTREKP EEALMTVRLK FLNETEEVAM
     VRPNDTIGML KSKYFPGQEQ QMKLIFQGQL LHDSSQTLCS LHITDNCVIH CHRSQATTPT
     SSSSPESGGS SQEHTGLTPP IGNLMIPVFV VMLALIWYFR INYRQFFTAP ATVSLVGVTV
     FFSFLVFGMY GR