ID   TMUB2_BOVIN             Reviewed;         322 AA.
AC   Q2HJA8;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Transmembrane and ubiquitin-like domain-containing protein 2;
GN   Name=TMUB2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP   [LARGE SCALE MRNA] OF 1-100 (ISOFORM 1).
RC   STRAIN=Hereford; TISSUE=Thalamus, and Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q2HJA8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q2HJA8-2; Sequence=VSP_019699;
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DR   EMBL; BC113228; AAI13229.1; -; mRNA.
DR   EMBL; DV881624; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001039999.1; NM_001046534.1. [Q2HJA8-2]
DR   AlphaFoldDB; Q2HJA8; -.
DR   SMR; Q2HJA8; -.
DR   STRING; 9913.ENSBTAP00000026199; -.
DR   PaxDb; Q2HJA8; -.
DR   PRIDE; Q2HJA8; -.
DR   GeneID; 614388; -.
DR   KEGG; bta:614388; -.
DR   CTD; 79089; -.
DR   eggNOG; ENOG502QU8U; Eukaryota.
DR   InParanoid; Q2HJA8; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR040352; TMUB1/2.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR14557; PTHR14557; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..322
FT                   /note="Transmembrane and ubiquitin-like domain-containing
FT                   protein 2"
FT                   /id="PRO_0000245311"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          174..247
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          88..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..20
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_019699"
SQ   SEQUENCE   322 AA;  33911 MW;  94AAE5253350CEA2 CRC64;
     MISRHLQNNL MSVDPVSSQA MELSDVTLIE GVGNEVTVVA GVVVLILALV LAWLSTYVAD
     SGSNPLLGTI VSAGDTSVLH LGHVDHLVAG QGTPEPTELP HPSEGNDEKA EEAGEGGGDP
     TGEPGAGGGV EPSLEHLLDI QGLPKRQAGP GNSSLEAPVR SEDSTCLPSS PSLISVRLKF
     FNDTEELAVA RPEDTVGALK SKYFPGQESQ MKLIYQGRLL QDPARTLRSL NITDNCVIHC
     HRSPPGSAVA GPSSSLAPSS TTEPPNLGVS VGSLMVPVFV VLLGVVWYFR INYRQFFTAP
     ATVSLVGVTV FFSFLVFGMY GR