BTBDJ_HUMAN
ID BTBDJ_HUMAN Reviewed; 291 AA.
AC C9JJ37; B4E384; B7ZC36; B7ZC37;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=BTB/POZ domain-containing protein 19;
GN Name=BTBD19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=C9JJ37-1; Sequence=Displayed;
CC Name=2;
CC IsoId=C9JJ37-2; Sequence=VSP_039226;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK304611; BAG65396.1; -; mRNA.
DR EMBL; AL592166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001130009.1; NM_001136537.1. [C9JJ37-1]
DR AlphaFoldDB; C9JJ37; -.
DR SMR; C9JJ37; -.
DR STRING; 9606.ENSP00000395461; -.
DR BioMuta; BTBD19; -.
DR MassIVE; C9JJ37; -.
DR PaxDb; C9JJ37; -.
DR PeptideAtlas; C9JJ37; -.
DR PRIDE; C9JJ37; -.
DR Antibodypedia; 58461; 25 antibodies from 9 providers.
DR DNASU; 149478; -.
DR Ensembl; ENST00000439563.2; ENSP00000410162.2; ENSG00000222009.8. [C9JJ37-2]
DR Ensembl; ENST00000450269.5; ENSP00000395461.1; ENSG00000222009.8. [C9JJ37-1]
DR GeneID; 149478; -.
DR KEGG; hsa:149478; -.
DR MANE-Select; ENST00000450269.6; ENSP00000395461.1; NM_001136537.3; NP_001130009.1.
DR UCSC; uc010ole.1; human. [C9JJ37-1]
DR CTD; 149478; -.
DR GeneCards; BTBD19; -.
DR HGNC; HGNC:27145; BTBD19.
DR HPA; ENSG00000222009; Low tissue specificity.
DR neXtProt; NX_C9JJ37; -.
DR OpenTargets; ENSG00000222009; -.
DR PharmGKB; PA165750488; -.
DR VEuPathDB; HostDB:ENSG00000222009; -.
DR eggNOG; KOG4350; Eukaryota.
DR GeneTree; ENSGT00940000162133; -.
DR HOGENOM; CLU_077764_0_0_1; -.
DR InParanoid; C9JJ37; -.
DR OMA; AHQCLLA; -.
DR OrthoDB; 940487at2759; -.
DR PhylomeDB; C9JJ37; -.
DR TreeFam; TF330633; -.
DR PathwayCommons; C9JJ37; -.
DR BioGRID-ORCS; 149478; 8 hits in 264 CRISPR screens.
DR GenomeRNAi; 149478; -.
DR Pharos; C9JJ37; Tdark.
DR PRO; PR:C9JJ37; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; C9JJ37; protein.
DR Bgee; ENSG00000222009; Expressed in left uterine tube and 116 other tissues.
DR ExpressionAtlas; C9JJ37; baseline and differential.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR042846; BTBD19.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR46965; PTHR46965; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..291
FT /note="BTB/POZ domain-containing protein 19"
FT /id="PRO_0000394239"
FT DOMAIN 29..98
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 134..234
FT /note="BACK"
FT VAR_SEQ 139..291
FT /note="VAVTFGLGQLQERCVAFIEAHSQEALRTRGFLELSAAALLPLLRSDKLCVDE
FT AELVRAARSWARVGAAVLERPVAEVAAPVVKELRLALLAPAELSALEEQNRQEPLIPVE
FT QIVEAWKCHALRRGDEARGAPCRRRRGTLPREHHRFLDLSFK -> HFWRPRRADQEVR
FT RSRPSWLTRWP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039226"
SQ SEQUENCE 291 AA; 32365 MW; 7105A23F9C2FCF62 CRC64;
MEPLGLVVHG KAEPFSAALR SLVNNPRYSD VCFVVGQERQ EVFAHRCLLA CRCNFFQRLL
GTEPGPGVPS PVVLSTVPTE AFLAVLEFLY TNSVKLYRHS VLEVLTAAVE YGLEELRELC
LQFVVKVLDV DLVCEALQVA VTFGLGQLQE RCVAFIEAHS QEALRTRGFL ELSAAALLPL
LRSDKLCVDE AELVRAARSW ARVGAAVLER PVAEVAAPVV KELRLALLAP AELSALEEQN
RQEPLIPVEQ IVEAWKCHAL RRGDEARGAP CRRRRGTLPR EHHRFLDLSF K
