ID   TMUB2_RAT               Reviewed;         319 AA.
AC   Q4FZV7; Q0P5P8;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Transmembrane and ubiquitin-like domain-containing protein 2;
GN   Name=Tmub2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; BC085794; AAH85794.1; -; mRNA.
DR   EMBL; BC099074; AAH99074.1; -; mRNA.
DR   RefSeq; NP_001026821.1; NM_001031651.2.
DR   RefSeq; XP_006247394.1; XM_006247332.2.
DR   AlphaFoldDB; Q4FZV7; -.
DR   SMR; Q4FZV7; -.
DR   STRING; 10116.ENSRNOP00000052057; -.
DR   PaxDb; Q4FZV7; -.
DR   Ensembl; ENSRNOT00000082722; ENSRNOP00000073316; ENSRNOG00000020916.
DR   GeneID; 303567; -.
DR   KEGG; rno:303567; -.
DR   UCSC; RGD:1304758; rat.
DR   CTD; 79089; -.
DR   RGD; 1304758; Tmub2.
DR   eggNOG; ENOG502QU8U; Eukaryota.
DR   GeneTree; ENSGT00390000014069; -.
DR   InParanoid; Q4FZV7; -.
DR   OMA; QMKFIYQ; -.
DR   OrthoDB; 1164744at2759; -.
DR   PhylomeDB; Q4FZV7; -.
DR   PRO; PR:Q4FZV7; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000020916; Expressed in Ammon's horn and 19 other tissues.
DR   Genevisible; Q4FZV7; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR040352; TMUB1/2.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR14557; PTHR14557; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..319
FT                   /note="Transmembrane and ubiquitin-like domain-containing
FT                   protein 2"
FT                   /id="PRO_0000245314"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          173..246
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          88..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          146..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        100..115
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   319 AA;  34022 MW;  9D6123F5757EA824 CRC64;
     MISRHLQNNL MSVDPVSSQA MELSDVTLIE GVGNEVMVVA GVVVLTLALV LAWLSTYVAD
     SSNSQLLGTI VSAGDTSVLH LGHVDQLVNQ GTPEPTEHPH PSGGSDDKAE ETSDSGGDTT
     GEPGARGDME PSLEHLLDIQ GLPKRQAGLE SSRPEASLGL DDSTCLSPSP SLINVRLKFL
     NDTEELAVAR PEDTVGTLKS KYFPGQESQM KLIYQGRLLQ DPARTLSSLN ITNNCVIHCH
     RSPPGAAVSG PSTSLTPTTE QSSLGVNVGS LMVPVFVVLL GVVWYFRINY RQFFTAPATV
     SLVGVTVFFS FLVFGMYGR