ID   TMX2_CAEEL              Reviewed;         265 AA.
AC   Q18484;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Thioredoxin-related transmembrane protein 2 homolog;
DE   AltName: Full=Thioredoxin domain-containing protein 14 homolog;
DE   Flags: Precursor;
GN   ORFNames=C35D10.10;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- DOMAIN: The thioredoxin domain lacks the 2 redox-active cysteines,
CC       suggesting that it lacks thioredoxin activity. {ECO:0000250}.
CC   -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum localization
CC       for type I membrane proteins. {ECO:0000250}.
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DR   EMBL; FO080789; CCD66783.1; -; Genomic_DNA.
DR   PIR; S72570; S72570.
DR   RefSeq; NP_498012.1; NM_065611.4.
DR   AlphaFoldDB; Q18484; -.
DR   SMR; Q18484; -.
DR   BioGRID; 40880; 1.
DR   STRING; 6239.C35D10.10; -.
DR   EPD; Q18484; -.
DR   PaxDb; Q18484; -.
DR   PeptideAtlas; Q18484; -.
DR   EnsemblMetazoa; C35D10.10.1; C35D10.10.1; WBGene00016446.
DR   GeneID; 175646; -.
DR   KEGG; cel:CELE_C35D10.10; -.
DR   UCSC; C35D10.10; c. elegans.
DR   CTD; 175646; -.
DR   WormBase; C35D10.10; CE01191; WBGene00016446; -.
DR   eggNOG; KOG0914; Eukaryota.
DR   GeneTree; ENSGT00390000003751; -.
DR   HOGENOM; CLU_064868_1_0_1; -.
DR   InParanoid; Q18484; -.
DR   OMA; FYTAWNP; -.
DR   OrthoDB; 1107509at2759; -.
DR   PhylomeDB; Q18484; -.
DR   PRO; PR:Q18484; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00016446; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043227; C:membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0015036; F:disulfide oxidoreductase activity; IBA:GO_Central.
DR   CDD; cd02962; TMX2; 1.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   InterPro; IPR037463; TMX2_thioredoxin_dom.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..265
FT                   /note="Thioredoxin-related transmembrane protein 2 homolog"
FT                   /id="PRO_0000315760"
FT   TOPO_DOM        33..96
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..265
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          126..230
FT                   /note="Thioredoxin"
FT   MOTIF           262..265
FT                   /note="Di-lysine motif"
SQ   SEQUENCE   265 AA;  30900 MW;  2D0731C464EA5060 CRC64;
     MLIPRLDEVR RALTAFHFFN TLLALAFPVI RSTSLCDYVF AVEGNEQCEI DSREREILMF
     LLIILAWKGR KATNWMHYVN NIFLFSKIAG MFLFIRADIL PGIIYILACL IVTVLFPEPV
     YNGPEQVTYF QGEQLFEELT RNRNTIWVIQ FFTTWSPECR HTSPVFAELS QKFTLPNMKF
     GKLDIGRWAK EGERFRVNAH PMSRQLPTIC VFKDAKEIAR RPLVNDSRRA VPFVFSEENC
     VLAFDLLNLY NEQKEKKGAK AKKED